江苏籍汉族系统性红斑狼疮与HLA-DR基因的相关性研究

Abstract

Abstract: To investigate the predisposing role of HLA-DR genes to systemic lupus erythematosus (SLE), We used polymerase chain reaction and sequence specific oligonucleotide (PCR/SSO) probe hybridization to type HLA-DR subregion in the patients with SLE of Han nationality from Jiangsu province and matched control subjects. The results indicated that DR2 gene frequency was significantly more frequent in patients than that in controls. Whereas DR4 significantly decreased in patients compared with controls. It suggests that DR2 or the other unidentified genes tightly linked to it might be the susceptible genes of SLE. Whereas DR4 might have a protective effect on SLE.

Key words: Lupus erythematosus,systemic, HLA-DR, PCR

Peng Xuebiao, Xu Wenyan, Yue Xiaoyu. Study on the Association Between HLA-DR Genes and Systemic Lupus Erythematosus in Jiangsu Chinese[J].Chinese Journal of Dermatology, 1997, 30(1): 7-9.

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Study on the Association Between HLA-DR Genes and Systemic Lupus Erythematosus in Jiangsu Chinese

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