Abstract: The neutxophils (PMN) from 24 cases of atopic diseases,the parents of 8 cases and 10 normal controls were studied by light-mictoscopic cytochemisty.The results revealaed that myeloperoxidase (MPO) and acid phosph atase (ACP) activities for all cases signzfica}tly decreased,no linear correlation was found between MPO and ACP; alkaline phosphatase activity was normal.The neutrophils from 7 cases' parents or parent revealed similar deficiency to thatCrom the patients.The results indicated that a combined and partial primary defiuency of MPO and ACP of PMN azurophilic gran ules eristed in the patients with atopic diseases.Presumably,the deficiency leads to lower PMN bactericidal ability and bactericidal delay; foreign bodies are degraded partially and tunred to be antigenic,and thus become an important cytobiological basis of susceptibility to infections and formation so sensitive antigen in atopic diseases.

Key words: Neutroghil Myeloperoxidase, Phosphornonoes terases, Atopic disease