Chinese Journal of Dermatology ›› 1992, Vol. 25 ›› Issue (5): 304-306.

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Biosynthesis of Platelet Activating Factor by Human Skin Keratinocytes in Vitro

LIU Bao-Jun1, ZHENG Mao-Rong1   

  1. Changhai Hospital, The Second Military Medical University, Shanghai 200433
  • Received:1991-05-07 Revised:1991-10-04 Online:1992-10-15 Published:1992-10-15

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Abstract: The synthesis and release of PAF by keratinocytes from normal human skin was investigated in vitro.When keratinotytes in suspension (1×108 cells) were stimulated with 2M Ca++ ionophore A23187,they synthesized a material that aggregated aspirin-treated washed rabbit platelet and way identified as PAF by four methods.

Key words: Platclct activating factor, Kerstinocytes