Chinese Journal of Dermatology ›› 1990, Vol. 23 ›› Issue (5): 305-307.

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Effect of 7, 12-dimethylbcuzanthracene on Thy-1 positive deaidritic epidermal cells, Langerhans cells and their relationship to tumor formation

ZHEN Li, CHEN Hong-Duo   

  1. The First Hospital, China Medical University, Shenyang
  • Received:1989-01-25 Revised:1989-05-17 Online:1990-10-15 Published:1990-10-15

Abstract: In murine skin there are two kinds of dendritie cells which, are derived from bone marrow and/or spleen, i.e. Thy-1 positive dendritic epidermal cells (Tliy-1+dEC) and Langerhans cells (LC). 7.12-Dimetyllbenzanthracene (DMBA) is a potent chemieal carcinogen which, when applied weekly to the mouse skin,causes the inductioa of skin tumors.