Abstract: The HLA-A,B antigen typing was invcstigated in 186 patients of Han nationality with atapic dermatitis (AD) (among them 42 PAD,62 ADR,33 ADI and 49 ADRI),compared to 22D healthy controls.Fwther more the DR antigen was studied in 63 patients (between them 30 PAD and 33 ADR),together with 105 controls.Increased frequency of A2 antigen wag shown statistically in all patient group (ADt) as well as in ADI subset,even after corrested for the number of A,B antigens tested (Pc=0.0209,RR=1.89 and Pc=0.0143,RR=3.64,respectively).The increased frequency of DR5 antigen in 63 patients,corrested P value was on the critical value (Pc≈0.05,RR=2.78).Ten haplotypes relatively susceptible to A were found,and A30-B13 was relatively resistant to ADt and four subsets of AD.Further analysis showed: 1.A2 antigen correlated strongly with floe female patients (RR=2.42); 2.B7 antigen correlated with family history of atopy (RR=3.70);3.B48 antigen correlated with fond allergy (RR=11.92).The associations among PAD,ADR,ADI or ADRI and HLA were multiantigenic and weak,and their relative antigens and haplotypes were different.The authors suggest that AD appears to be a disease of heterogeneous nature.