Abstract: The results of the detection attd identification of antibodies to saline extractable nuclear antigens in 58.patients with systemic.lupus erpthematosus(SLE) by counterimmunoelectrophoresis are reported in this article.The serologic specificity of the precipitin lines.formed were identified by matching them to those of reference sera.Antibodies to La(SS-B),nncIear RNP and Sm were detected in one,15(25.86%) and 19(32.75%) patients with SLE respectively.