Effect of amphotericin B on the production of tumor necrosis factor-α and interleukin-8 and activation of signaling molecule p38MAPK in human THP-1 cells
Ye Wenxia, Du Leilei, DuanZhimin, Liu Caixia, Li Min, Gao Yu#br#
Department of Dermatology, The 2nd Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang, China(Ye WX[current affiliation: Department of Dermatology, Lishui People′s Hospital, The Sixth Affiliated Hospital of Wenzhou Medical University, Lishui 323000, Zhejiang, China], Gao Y); Department of Mycology, Hospital of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing 210042, China(Du LL, Duan ZM, Liu CX, Li M)
;National Basic Research Program (973 Program) of China;333 High-level Talents Training Project of Jiangsu Province;Six Talents Peak Project of Jiangsu Province
Ye Wenxia, Du Leilei, Duan Zhimin, Liu Caixia, Li Min, Gao Yu. Effect of amphotericin B on the production of tumor necrosis factor-α and interleukin-8 and activation of signaling molecule p38MAPK in human THP-1 cells[J]. Chinese Journal of Dermatology, 2017, 50(10): 729-732.doi:10.3760/cma.j.issn.0412-4030.2017.10.008
Matsuo K, Hotokezaka H, Ohara N, et al. Analysis of amphotericin B⁃induced cell signaling with chemical inhibitors of signaling molecules[J]. Microbiol Immunol, 2006, 50(4): 337⁃347.
[3]
Muenster S, Bode C, Diedrich B, et al. Antifungal antibiotics modulate the pro⁃inflammatory cytokine production and phagocytic activity of human monocytes in an in vitro sepsis model[J]. Life Sci, 2015, 141: 128⁃136. DOI: 10.1016/j.lfs.2015.09.004.
[4]
Hedges JF, Mitchell AM, Jones K, et al. Amphotericin B stimulates γδ T and NK cells, and enhances protection from Salmonella infection[J]. Innate Immun, 2015, 21(6): 598⁃608. DOI: 10.1177/1753425914567692.
[5]
Mesa⁃Arango AC, Scorzoni L, Zaragoza O. It only takes one to do many jobs: amphotericin B as antifungal and immunomodulatory drug[J]. Front Microbiol, 2012, 3: 286. DOI: 10.3389/fmicb.2012. 00286.
[6]
Herring AC, Falkowski NR, Chen GH, et al. Transient neutrali⁃zation of tumor necrosis factor alpha can produce a chronic fungal infection in an immunocompetent host: potential role of immature dendritic cells[J]. Infect Immun, 2005, 73(1): 39⁃49. DOI: 10.1128/IAI.73.1.39⁃49.2005.
[7]
Bellocchio S, Gaziano R, Bozza S, et al. Liposomal amphotericin B activates antifungal resistance with reduced toxicity by diverting Toll⁃like receptor signalling from TLR⁃2 to TLR⁃4[J]. J Antimicrob Chemother, 2005, 55(2): 214⁃222. DOI: 10.1093/jac/dkh542.