自身免疫相关B细胞在自身免疫性疾病中的作用

doi:10.35541/cjd.20230715

Abstract

Abstract: 【Abstract】 Autoimmune/age?associated B cells are a phenotypically and functionally distinct B cell subset that accumulates with age. In addition to producing antibodies, these cells participate in inflammatory responses by activating T?cell function and secreting cytokines. Accumulating evidence indicates that autoimmune?associated B cells are abnormally expanded in autoimmune diseases and play a critical role in their pathogenesis. This review summarizes the characteristics, origins, and functions of autoimmune?associated B cells, as well as their potential pathogenic mechanisms in autoimmune diseases such as systemic lupus erythematosus and rheumatoid arthritis.

Key words: Autoimmune?associated B cells, Age?associated B cells, Autoimmunity

Shen Yiting, Zhu Haiqin, Zhang Huihui, Pan Meng. Role of autoimmune-associated B cells in autoimmune diseases[J]. Chinese Journal of Dermatology,2026,e20230715. doi:10.35541/cjd.20230715

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Role of autoimmune-associated B cells in autoimmune diseases

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