[开放获取]   特发性光线性皮肤病的光硬化治疗

doi:10.35541/cjd.20230347

Abstract

Abstract: 【Abstract】 Photohardening therapy, also known as photodesensitization therapy, refers to the phototherapy and photochemotherapy of idiopathic actinic dermatoses, and its goal is to improve the patients′ tolerance to sunlight and prevent disease flares. Its mechanisms of action involve a variety of cellular and inflammatory factors. This therapy is suitable for all idiopathic actinic dermatoses, with definite efficacy and good safety. However, the treatment specificity usually leads to poor compliance. The development of UVA1 rush hardening and home phototherapy is expected to solve this problem.

Key words: Photosensitivity disorders, Idiopathic actinic dermatoses, Photohardening therapy, Photodesensitization therapy, UVA1 rush hardening, Home phototherapy

Deng Huiyan, Chen Jiaoquan, Li Huaping, Chen Quan, Zhang Sanquan, Zhu Huilan. Photohardening therapy for idiopathic actinic dermatoses[J]. Chinese Journal of Dermatology, 2023, 56(12): 1091-1095.doi:10.35541/cjd.20230347

References ［40］

［1］	Schweintzger N, Gruber⁃Wackernagel A, Reginato E, et al. Levels and function of regulatory T cells in patients with polymorphic light eruption: relation to photohardening［J］. Br J Dermatol, 2015,173（2）:519⁃526. doi: 10.1111/bjd.13930.
［2］	Becker SW Jr. Prevention of sunburn and light allergy with methoxsalen［J］. GP, 1959,19（3）:115⁃117.
［3］	Rathod DG, Muneer H, Masood S. Phototherapy［M/OL］. StatPearls ［Internet］. Treasure Island （FL）:StatPearls Publishing, 2023［2023⁃08⁃30］. https://www.ncbi.nlm.nih.gov/books/NBK563140/.
［4］	中国康复医学会皮肤病康复专业委员会, 中国医学装备协会皮肤病与皮肤美容分会光医学治疗装备学组. 紫外线治疗皮肤病临床应用专家共识［J］. 中华皮肤科杂志, 2019,52（12）:872⁃877. doi: 10.35541/cjd.20190617.
［5］	中国研究型医院学会皮肤科学专业委员会, 中国医师协会皮肤科医师分会. 长波紫外线1皮肤科临床应用专家共识（2022）［J］. 中华皮肤科杂志, 2022,55（11）:956⁃961. doi: 10.35541/cjd.20220423.
［6］	Kurz B, Berneburg M, Bäumler W, et al. Phototherapy: theory and practice［J］. J Dtsch Dermatol Ges, 2023,21（8）:882⁃897. doi: 10.1111/ddg.15126.
［7］	Kappes UP, Barta U, Merkel U, et al. High plasma levels of 8⁃methoxypsoralen following bath water delivery in dermatological patients［J］. Skin Pharmacol Appl Skin Physiol, 2003,16（5）:305⁃312. doi: 10.1159/000072070.
［8］	Hönigsmann H. Mechanisms of phototherapy and photo⁃chemotherapy for photodermatoses［J］. Dermatol Ther, 2003,16（1）:23⁃27. doi: 10.1046/j.1529⁃8019.2003.01604.x.
［9］	Wolf P, Gruber⁃Wackernagel A, Bambach I, et al. Photo⁃hardening of polymorphic light eruption patients decreases baseline epidermal Langerhans cell density while increasing mast cell numbers in the papillary dermis［J］. Exp Dermatol, 2014,23（6）:428⁃430. doi: 10.1111/exd.12427.
［10］	Goetze S, Elsner P. Solar urticaria［J］. J Dtsch Dermatol Ges, 2015,13（12）:1250⁃1253. doi: 10.1111/ddg.12809.
［11］	Kadurina M, Kazandjieva J, Bocheva G. Immunopathogenesis and management of polymorphic light eruption［J］. Dermatol Ther, 2021,34（6）:e15167. doi: 10.1111/dth.15167.
［12］	Patra V, Gallais Sérézal I, Wolf P. Potential of skin microbiome, pro⁃ and/or pre⁃biotics to affect local cutaneous responses to UV exposure［J］. Nutrients, 2020,12（6）:1795. doi: 10.3390/nu12061795.
［13］	Jiang AJ, Lim HW. Phototherapy in the evaluation and management of photodermatoses［J］. Dermatol Clin, 2020,38（1）:71⁃77. doi: 10.1016/j.det.2019.08.007.
［14］	孙思昊. 慢性光化性皮炎问卷调查分析及光硬化治疗临床观察［D］. 昆明: 昆明医科大学, 2022.
［15］	Krutmann J, Hönigsmann H, Elmets CA, et al. 皮肤病光疗和光诊断学方法［M］. 朱慧兰, 王建琴, 译. 2版. 北京: 人民卫生出版社, 2017:102⁃114.
［16］	Oakley AM, Ramsey ML. Polymorphic light eruption［M/OL］. StatPearls ［Internet］. Treasure Island （FL）: StatPearls Publishing, 2023［2023⁃08⁃30］. https://www.ncbi.nlm.nih.gov/books/NBK430886/.
［17］	Bilsland D, George SA, Gibbs NK, et al. A comparison of narrow band phototherapy （TL⁃01） and photochemotherapy （PUVA） in the management of polymorphic light eruption［J］. Br J Dermatol, 1993,129（6）:708⁃712. doi: 10.1111/j.1365⁃2133.1993.tb03337.x.
［18］	Libon F, Nikkels AF. Polymorphous light eruption: phototherapy⁃based desensitization versus intramuscular steroids ⁃ who is right, who is wrong?［J］. Dermatology, 2018,234（5⁃6）:192⁃193. doi: 10.1159/000492749.
［19］	Lembo S, Raimondo A. Polymorphic light eruption: what′s new in pathogenesis and management［J］. Front Med （Lausanne）, 2018,5:252. doi: 10.3389/fmed.2018.00252.
［20］	Wang T, Gong Y, Rong W, et al. Ultraviolet A rush hardening for chronic actinic dermatitis: pilot treatment outcomes［J］. J Dermatol, 2021,48（3）:385⁃388. doi: 10.1111/1346⁃8138.15667.
［21］	孙思昊, 李晔, 农祥, 等. 慢性光化性皮炎发病机制及治疗［J］. 皮肤病与性病, 2021,43（3）:345⁃347. doi: 10.3969/j.issn.1002⁃1310.2021.03.010.
［22］	Khaled A, Kerkeni N, Baccouche D, et al. Chronic actinic dermatitis: two patients with successful management using narrowband ultraviolet B phototherapy with systemic steroids［J］. Therapie, 2011,66（5）:453⁃457. doi: 10.2515/therapie/2011052.
［23］	Jury CS, McHenry P, Burden AD, et al. Narrowband ultraviolet B （UVB） phototherapy in children［J］. Clin Exp Dermatol, 2006,31（2）:196⁃199. doi: 10.1111/j.1365⁃2230.2006.02061.x.
［24］	Collins P, Ferguson J. Narrow⁃band UVB （TL⁃01） phototherapy: an effective preventative treatment for the photodermatoses［J］. Br J Dermatol, 1995,132（6）:956⁃963. doi: 10.1111/j.1365⁃2133.1995.tb16955.x.
［25］	Gaebelein⁃Wissing N, Ellenbogen E, Lehmann P. Solar urticaria: clinic, diagnostic, course and therapy management in 27 patients［J］. J Dtsch Dermatol Ges, 2020,18（11）:1261⁃1268. doi: 10. 1111/ddg.14309.
［26］	Masuoka E, Fukunaga A, Kishigami K, et al. Successful and long⁃lasting treatment of solar urticaria with ultraviolet A rush hardening therapy［J］. Br J Dermatol, 2012,167（1）:198⁃201. doi: 10.1111/j.1365⁃2133.2012.10944.x.
［27］	顾恒, 常宝珠, 陈崑. 光皮肤病学［M］. 北京: 人民军医出版社, 2009.
［28］	Vellaichamy G, Chadha AA, Hamzavi IH, et al. Polymorphic light eruption sine eruptione: a variant of polymorphous light eruption［J］. Photodermatol Photoimmunol Photomed, 2020,36（5）:396⁃397. doi: 10.1111/phpp.12565.
［29］	Aslam A, Fullerton L, Ibbotson SH. Phototherapy and photochemotherapy for polymorphic light eruption desensiti⁃zation: a five⁃year case series review from a university teaching hospital［J］. Photodermatol Photoimmunol Photomed, 2017,33（4）:225⁃227. doi: 10.1111/phpp.12310.
［30］	Attili SK, Dawe RS, Ibbotson SH. Ultraviolet A1 phototherapy: one center′s experience［J］. Indian J Dermatol Venereol Leprol, 2017,83（1）:60⁃65. doi: 10.4103/0378⁃6323.182805.
［31］	Snast I, Kremer N, Lapidoth M, et al. Omalizumab for the treatment of solar urticaria: case series and systematic review of the literature［J］. J Allergy Clin Immunol Pract, 2018,6（4）:1198⁃1204.e3. doi: 10.1016/j.jaip.2018.02.032.
［32］	Matthews SW, Sherman KJ, Binick S, et al. Optimizing narrowband UVB phototherapy: is it more challenging for your older patients?［J］. Cutis, 2022,110（2）:E45⁃E52. doi: 10.12788/cutis.0617.
［33］	Slimani Y, Elfatoiki FZ, Skali HD, et al. Phototherapy in children: epidemiology, clinical profile, and outcome［J］. Photodermatol Photoimmunol Photomed, 2021,37（3）:224⁃225. doi: 10.1111/phpp.12637.
［34］	Murase JE, Heller MM, Butler DC. Safety of dermatologic medications in pregnancy and lactation: part I. Pregnancy［J］. J Am Acad Dermatol, 2014,70（3）:401.e1⁃401.e14. doi: 10. 1016/j.jaad.2013.09.010.
［35］	Butler DC, Heller MM, Murase JE. Safety of dermatologic medications in pregnancy and lactation: partⅡ. Lactation［J］. J Am Acad Dermatol, 2014,70（3）:417.e1⁃417.e10. doi: 10. 1016/j.jaad.2013.09.009.
［36］	Franken SM, Genders RE, de Gruijl FR, et al. Skin hardening effect in patients with polymorphic light eruption: comparison of UVB hardening in hospital with a novel home UV⁃hardening device［J］. J Eur Acad Dermatol Venereol, 2013,27（1）:67⁃72. doi: 10.1111/j.1468⁃3083.2011.04358.x.
［37］	Ontario Health （Quality）. Home narrowband ultraviolet B phototherapy for photoresponsive skin conditions: a health technology assessment［J］. Ont Health Technol Assess Ser, 2020,20（12）:1⁃134.
［38］	Bawany F, Ryan Wolff J, Ritchlin CT, et al. Home phototherapy improves access to dermatologic care: a novel stakeholder alliance to facilitate its implementation［J］. Clin Cosmet Investig Dermatol, 2023,16:1175⁃1180. doi: 10.2147/CCID.S408323.
［39］	Jacob J, Pona A, Cline A, et al. Home UV phototherapy［J］. Dermatol Clin, 2020,38（1）:109⁃126. doi: 10.1016/j.det.2019.09. 001.
［40］	中国医师协会皮肤科医师分会规范化诊疗工作委员会, 中国医学装备协会皮肤病与皮肤美容专业委员会皮肤外科装备学组和皮肤光治疗学组. 窄谱中波紫外线家庭光疗临床应用专家共识［J］. 中华皮肤科杂志, 2019,52（3）:156⁃161. doi: 10. 3760/cma.j.issn.0412⁃4030.2019.03.002.

[1]	Chen Quan, Tang Yi, Li Huaping, Wu Weihong, Deng Huiyan, Chen Jiaoquan, Chen Lezi, Li Zhenjie, Zhu Huilan. Characterisation of serum lipidomic profiles in patients with chronic actinic dermatitis based on liquid chromatography-mass spectrometry [J]. Chinese Journal of Dermatology, 2023, 56(12): 1107-1114.
[2]	Chen Kun, Gu Heng. Research progress and directions in photodermatology [J]. Chinese Journal of Dermatology, 2023, 56(12): 1087-1090.
[3]	Li Lingjia, Liu Tongyun . Expression of caspase-14 in skin lesions of patients with chronic actinic dermatitis and effect of ultraviolet B radiation on its mRNA and protein expression in HaCaT cells [J]. Chinese Journal of Dermatology, 2019, 52(7): 486-490.
[4]	WANG Li-ying, CHEN Kum, GU Heng, CHANG Bao-zhu, ZHENG Jia-run. The Action Spectrum of Ultraviolet Light in Chronic Actinic Dermatitis [J]. Chinese Journal of Dermatology, 2005, 38(7): 410-412.
[5]	CHEN Hao, DENG Dan-qi, ZHOU Xiao-hong, FAN Ying-jun, YANG Hong-ying. Imbalance of Tc Cells in the Pathogenesis of Chronic Actinic Dermatitis [J]. Chinese Journal of Dermatology, 2005, 38(10): 628-630.
[6]	HU Yue, XU Yu, YAN Chunlin. Study on Chlorpromazine Induced Photohemolysis Under Exposure to UV-irradiation in Vitro [J]. Chinese Journal of Dermatology, 2000, 33(4): 269-271.
[7]	Hu Yue, Yan Chunlin, Liao Kanghuang. Study on Photohemolysis in Assessment of Chlorpromazine Phototoxicity in vitro [J]. Chinese Journal of Dermatology, 1997, 30(6): 377-379.

Photohardening therapy for idiopathic actinic dermatoses

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