Chinese Journal of Dermatology ›› 2022, Vol. 55 ›› Issue (2): 177-181.doi: 10.35541/cjd.20200014

• Reviews • Previous Articles     Next Articles

Bullous pemphigoid and its immune-mediated comorbidities

Zhao Wenling, Yang Yuyan, Li Li, Jin Hongzhong   

  1. Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China
  • Received:2020-01-06 Revised:2020-08-11 Online:2022-02-15 Published:2022-01-27
  • Contact: Li Li
  • Supported by:
    National Key Research and Development Program of China (2016YFC0901500); National Natural Science Foundation of China (81972945); Education Reform Projects of Peking Union Medical College (2016zlgc0106); Funds of Shunyi District for Health Improvement and Research(Wsjkfzkyzx-2019-y-07)

Abstract: 【Abstract】 Bullous pemphigoid (BP) can be comorbid with a variety of immune diseases, such as immune skin diseases (psoriasis, vitiligo, alopecia areata and various other immune bullous diseases), immune diseases of the digestive system (inflammatory bowel disease, primary biliary cirrhosis), autoimmune thyroid diseases, autoimmune rheumatic diseases (rheumatoid arthritis, dermatomyositis, scleroderma and systemic lupus erythematosus), immune renal diseases (immune nephropathy, renal allograft rejection) and acquired hemophilia A. The above comorbidities markedly affect the quality of life of and treatment options for patients. This review elaborates currently reported immune diseases associated with BP and their concomitant mechanisms.

Key words: Pemphigoid, bullous, Immune system diseases, Cross reactions, Epitope spreading, Multiple autoimmune syndrome