普萘洛尔治疗婴儿血管瘤的研究进展

doi:10.35541/cjd.20191042

Abstract

Abstract: 【Abstract】 Propranolol is a non-selective β-adrenoceptor blocker. Various studies have confirmed that it is safe and effective for the treatment of infantile hemangioma. The mechanism of action mainly includes: （1） pericyte-mediated hemodynamic changes and subsequent effects; （2） inhibiting proliferation of hemangioma-derived endothelial cells and stem cells by blocking cell cycle progression, inducing apoptosis of hemangioma-derived endothelial cells and differentiation of hemangioma-derived stem cells into adipocytes; （3） inhibiting the recruitment of endothelial progenitor cells; （4） reducing levels of pro-angiogenic factors, such as vascular endothelial growth factor, matrix metalloproteinase, etc.

Key words: Hemangioma, Infant, Propranolol, Hemodynamics, Endothelial cells, Vascular endothelial growth factors, Matrix metalloproteinases

Ji cong Jiang Jianming Wu. Propranolol for the treatment of infantile hemangioma[J]. Chinese Journal of Dermatology, 2020, 53(7): 573-576.doi:10.35541/cjd.20191042

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Propranolol for the treatment of infantile hemangioma

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