中华皮肤科杂志 ›› 1996, Vol. 29 ›› Issue (2): 82-84.

• 论著 • 上一篇    下一篇

银屑病患者白介素6和肿瘤坏死因子α的测定

陈周1, 饶汉珍2, 郭实士3   

  1. 1. 北京医科大学人民医院皮肤科 100044;
    2. 湖南医科大学湘雅医院皮肤科;
    3. 湖南医科大学免疫研究室
  • 收稿日期:1994-12-06 修回日期:1995-04-11 出版日期:1996-04-15 发布日期:1996-04-15

Detection of Interleukin-6 and Tumor Necrosis Factor-alpha in Patients with Psoriasis Vulgaris

Chen Zhou1, Rao Hanzhen2, Guo Shishi3   

  1. Department of Dermatology, People's Hospital, Beijing Medical University, Beijing 100044
  • Received:1994-12-06 Revised:1995-04-11 Online:1996-04-15 Published:1996-04-15

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摘要： 用生物活性测定法对49例寻常型银屑病患者和20例正常人外周血单一核细胞(PBMC)体外产生白介素6(IL6)和肿瘤坏死因子α(TNFα)的能力及其血清水平进行了测定,并对其相关性进行了分析。结果:患者PBMC产生IL6、TNFα的能力及其血清水平均高于正常人;PBMC产生IL6、TNFα的能力与其血清水平呈正相关;血清IL6与TNFα水平呈正相关。

关键词: 银屑病, 白介素6, 肿瘤坏死因子-α

Abstract: The activities of interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNFα) produced by peripheral blood mononuclear cells (PBMCs) in vitro and their relevant levels in sera were measured in 49 patients with psoriasis vulgaris (PV) and in 20 normal controls using bioassay. The relationship between them was also analysed. The results showed that in PV patients the activites of IL-6 and TNFα produced by PBMCs and their serum levels were higher than those in healthy controls. There was a positive linear correlation between the activites in vitro and relevant levels in sera, and a positive linear correlation between serum levels of IL-6 and TNFα. These results indicate that there is dysfunction of cellular immune of PBMCs in PV patients. The increase of serum levels of IL-6 and TNFα may be related to the increased activity of PBMCs, and there may be a synergic action between IL-6 and TNFα in the pathogenesis of psoriasis.

Key words: Psoriasis, Interleukin 6, Tumor necrosis factor-alpha