中华皮肤科杂志 ›› 1996, Vol. 29 ›› Issue (2): 77-79.

• 论著 • 上一篇    下一篇

CD44分子在银屑病患者表皮的表达

杨雪琴1, 张海涛2, Lida Naoko3, Taylor J R3, 夏松澜3   

  1. 1. 北京空军总医院皮肤科 100036;
    2. 沈阳军区总医院皮肤科;
    3. 美国迈阿密大学医学院
  • 收稿日期:1995-01-22 修回日期:1995-08-20 出版日期:1996-04-15 发布日期:1996-04-15

Expression of CD44 Molecules in Psoriatic Epidermis

Yang Xueqin1, Zhang Haitao2, Lida Naoko3   

  1. Department of Dermatology, Airforce General Hospital, Beijing 100036
  • Received:1995-01-22 Revised:1995-08-20 Online:1996-04-15 Published:1996-04-15

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摘要： 采用免疫组化染色研究银屑病患者损害、无损害及治愈后皮肤的CD44分子表达。发现CD44呈现在表皮的棘细胞和基底细胞表面;银屑病损害处比无损害处及治愈后皮肤要显着得多,呈高表达。用逆转录聚合酶链反应分析CD44的类型,结果主要为CD44的标准型,即CD44S,也有CD44E型,未见到CD44V型。本研究提示CD44的高表达可能与银屑病损害表皮细胞过度增生有关,CD44S型及CD44E型可能提示良性增生。

关键词: 银屑病, CD44

Abstract: The expression of CD44 in psoriatic epidermis was studied with immunohistochemical staining. Overexpression of CD44-was observed in involved proliferative epidermis as compared with uninvolved and cured epidermis in psoriatic patient. Several CD44-isoforms based on analysis by reverse-transcriptase polymerase chain reaction (RT-PCR) were mainly CD44 S and CD44 E. These results suggest that CD44 may be an important substance in the proliferation of keratinocytes, such as psoriasis.

Key words: Psoriasis CD44