中华皮肤科杂志 ›› 1997, Vol. 30 ›› Issue (4): 224-226.

• 论著 • 上一篇    下一篇

白癜风患者血清及皮肤组织液可溶性白介素2受体的检测

涂彩霞, 傅红文, 林熙然   

  1. 大连医科大学附属第一医院皮肤科, 辽宁 116011
  • 收稿日期:1996-06-03 修回日期:1996-09-28 出版日期:1997-08-15 发布日期:1997-08-15

Levels of Soluble Interleukin-2 Receptor in the Sera and Skin Tissue Fluids of Patients with Vitiligo

Tu Caixia, Fu Hongwen, Lin Xiran   

  1. Department of Dermatology, The First Affiliated Hospital of Dalian Medical University, Dalian 116011
  • Received:1996-06-03 Revised:1996-09-28 Online:1997-08-15 Published:1997-08-15

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摘要： 为了探讨可溶性白介素2受体(sIL-2R)在白癜风发病中的作用,采用单克隆与多克隆双抗体夹心法,对41例白癜风患者血清及白斑部位和无病变部位皮肤组织液中sIL-2R水乎进行了测定。结果显示:白癜风患者血清sIL-2R水平明显高于正常对照组(P<0.01),其中寻常型与对照组相比有显著性差异(P<0.01),而节段型与对照组相比无显著性差异(P>0.05);进展期白癜风患者血清中sIL-2R水平明显高于稳定期(P<0.01);同一患者的白斑部位皮肤组织液中sIL-2R含量明显高于无病变部位(P<0.05)。本研究提示sIL-2R的表达与白癜风的发病有关,血清中sIL-2R水平与白癜风的活动性有一定关系,检测其含量对估计病情及判断预后可能具有意义。

关键词: 白癜风, 受体, 白细胞介素2

Abstract: In order to study the possible role of soluble interleukin-2 receptor (slL-2R) in the pathogenesis of vitiligo, we measured the levels of slL-2R in the sera and the tissue fluids from skin lesions and uninvolved skin from 41 patients with vitiligo, using the method of sandwich ELISA with monoclonal and polyclonal antibodies. The results showed that the overall level of serum sIL-2R from patients with vitiligo was significantly higher, than that from normal control group (P<0.01). The serum level of sIL-2R in the common type was significantly higher than that in normal control group(P<0.01), but there was no significant difference between the segmental type and normal control group (P>0.05). The level of serum sIL-2R from patients with vitiligo in progressive stage was significantly higher than that in stable stage (P<0.01). The level of sIL-2R in the tissue fluid from the skin lesion of the patient was significantly higher than uninvolved skin of the same patient (P<0.05). The above data indicate that there is an association between the expression of sIL-2R and the pathogenesis of vitiligo. The level of serum sIL-2R in vitiligo is related to the activity of the disease, therefore the measurement of it may be significant in estimating the severity and the prognosis of the disease.

Key words: Vitiligo, Receptor, interleukin-2