中华皮肤科杂志 ›› 2005, Vol. 38 ›› Issue (6): 357-359.

• 论著 • 上一篇    下一篇

HLA-DQA1和HLA-DQB1等位基因与皖籍汉族人群白癜风的相关性

汪继云, 杨森, 王红艳, 刘宏胜, 孙良丹, 高敏, 何平平, 崔勇, 张学军   

  1. 安徽医科大学皮肤病研究所、第一附属医院皮肤性病科 合肥 230022
  • 收稿日期:2004-06-23 出版日期:2005-06-15 发布日期:2005-06-15
  • 通讯作者: 张学军,E-mail:ayzxj@mail.hf.ah.cn E-mail:ayzxj@mail.hf.ah.cn
  • 基金资助:
    国家863计划课题(2001AA227031);安徽省自然科学基金项目(01043705)

Association of HLA-DQA1,-DQB1 Genes with Vitiligo in Chinese Hans in Anhui Province

WANG Ji-yun, YANG Sen, WANG Hong-yan, LIU Hong-sheng, SUN Liang-dan, GAO Min, HE Ping-ping, CUI Yong, ZHANG Xue-jun   

  1. Institute of Dermatology, Anhui Medical University, Department of Dermatology and Venereology, The First Affiliated Hospital, Anhui Medical College, Hefei 230022, China
  • Received:2004-06-23 Online:2005-06-15 Published:2005-06-15

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摘要： 目的 探讨HLA-DQA1、-DQB1等位基因与皖籍汉族人群白癜风的相关性。方法 采用聚合酶链反应-序列特异性引物(PCR-SSP)方法,检测白癜风患者的HLA-DQA1、-DQB1等位基因。结果 与正常人对照组比较,①白癜风患者HLA-DQA1*0302、-DQB1*0303、-DQB1*0503等位基因频率显著升高,HLA-DQA1*0501等位基因频率显著降低;②HLA-DQA1*0302、-DQA1*0601、-DQB1*0303、-DQB1*0503等位基因频率在儿童型白癜风患者中显著升高,HLA-DQA1*0501等位基因频率显著下降;而成人型白癜风患者HLA-DQB10303等位基因频率显著升高;③HLA-DQA1*0302、-DQB1*0303、-DQB1*0503等位基因频率在泛发型白癜风患者中显著升高,HLA-DQA1*0501等位基因频率显著下降;而局限型白癜风患者HLA-DQB1*0303等位基因显著升高。结论 HLA-DQA1*0302、-DQA1*0601、-DQB1*0303、-DQB1*0503、-DQA1*0501等位基因可能与白癜风相关,不同类型白癜风在其遗传背景上可能存在异质性。

关键词: 白癜风, 基因,MHCⅡ类

Abstract: Objective To identify the association of HLA-DQA1 and-DQ B1 alleles with vitiligo in Chinese Hans in Anhui province. Methods Polymerase chain reaction sequence-specific primer (PCR-SSP) method was used to analyze the distribution of HLA-DQA1 and-DQB1 alleles among 187 patients with vitiligo and 273 healthy controls. Results The frequencies of HLA-DQA1*0302,-DQB1*0303,-DQB1*0503 alleles were significantly increased in the patients with vitiligo compared with those in the controls,and HLA-DQA1*0501 allele frequency was mark edly decreased.HLA-DQA1*0302,-DQA1*0601,-DQB1*0303,-DQB1*0503 alleles were positively associated,whereas HLA-DQA1*0501 allele was negatively associated with childhood vitiligo,and HLA-DQB1*0303 allele was positively associated with adultvitiligo,in comparison with those in the controls.The frequency of HLA-DQB 1*0303 allele was significantly increased in localized vitiligo patients compared with that in the controls,whereas frequencies of HLA-DQA1*0302,-DQB1*0303,-DQB1*0503 alleles were significantly increased and the frequency of HLA-DQA1*0501 allele was markedly decreased in generalized vitiligo patients. Conclusions HLA-DQA1*0302,-DQA1*0601,-DQB1*0303 and-DQB1*0503 alleles could be the suscep tible alleles of vitiligo,while HLA-DQA1*0501 allele could be the protective al lele in Chinese Hans in Anhui province.There may be different genetic backgrounds between childhood and adult patients,and between localized and generalized vitiligo.

Key words: Vitiligo, Genes, MHC classⅡ