中华皮肤科杂志 ›› 2000, Vol. 33 ›› Issue (6): 407-409.

• 论著 • 上一篇    下一篇

北方汉族白癜风患者HLA-Ⅰ类抗原相关性研究

王岩1, 肖毅1, 赵玉铭1, 刘永学2, 王良明3, 高德凯2, 宋芳吉1, 陈洪铎1   

  1. 1. 中国医科大学第一临床学院皮肤科 沈阳 110001;
    2. 解放军第81301部队医院皮肤科;
    3. 沈阳军区总医院皮肤科
  • 收稿日期:1999-12-15 出版日期:2000-12-15 发布日期:2000-12-15

Study on Association Between Vitiligo and HLA ClassⅠ Antigens

WANG Yan1, XIAO Yi1, ZHAO Yuming1   

  1. Department of Dermatology, No.1 Hospitol of China Medical University, Shenyang 110001
  • Received:1999-12-15 Online:2000-12-15 Published:2000-12-15

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摘要： 目的 探讨中国北方汉族人群中白癜风与HLA-Ⅰ类抗原的相关性。方法 白癜风患者95例,采用HLA血清学分型技术检测HLA-A、B位点的抗原特异性,并与100例正常人进行比较。结果 ①白癜风患者HLA-A2、A10、A30+31、B13、B15抗原频率显著增高(Pc<0.01);HLA-A28、B46抗原频率显著降低(Pc<0.01)。②有明确家族史的白癜风患者HLA-A10、B13、B15抗原频率显著增高(Pc<0.01);无家族史的HLA-A2、A30+31、B13、B15、B40抗原频率显著增高(Pc<0.01);将家族史阳性与阴性的患者进行比较,仅发现HLA-B13抗原有差异(Pc<0.05)。③与对照组比较,散发型患者HLA-A10、A30+31、B13、B15及限局型患者HLA-A2、A30+31、B13、B15、B40差异有显著性(Pc<0.01);肢端型患者HLA-B13及节段型患者HLA-A30+31、B13差异有显著性(Pc均<0.01)。结论 白癜风患者HLA-A2、A10、A30+31、B13、B15抗原频率增高,HLA-A28、B46抗原频率降低。家族史阳性及阴性患者及各临床分型间HLA-Ⅰ类抗原差异亦有显著性。该结果为进一步揭示白癜风的免疫遗传机制提供了线索,亦提示北方汉族白癜风在免疫遗传上有一定的特性。

关键词: 白癜风, 组织相容性抗原Ⅰ类

Abstract: Objective To investigate the association between vitiligo and HLA classⅠ antigens in the Northern Han Chinese. Methods Ninety-five patients with vitiligo and 100 normal controls were tested for HLA-A,B antigens by standard microcytotoxicity assay. Results ① It was found that HLA-A2,A10,A30+31,B13,B15 antigen frequencies were significantly higher in vitiligo patients than those in the controls, while HLA-A28,B46 antigen frequencies were markedly lower in vitiligo patients (Pc< 0.01).② There was a significant association of HLA-A10,B13,B15 with familial vitiligo patients, whereas non-familial patients were associated with HLA-A2,A30+31,B13,B15, B40 (Pc< 0.01). When familial patients were compared with non-familial patients, HLA-B13 was different in frequency between the two groups (Pc< 0.05).③ HLA-A10,A30+31,B13 and B15 were significantly increased in the scattered type of vitiligo while HLA-A2,A30+31,B13,B15 and B40 were significantly increased in the localized type. HLA-B13 was significantly increased in the acral type of vitiligo while HLA-A30+31,B13 were significantly increased in the segmental type. Conclusions The results indicate that vitiligo is positively associated with HLA-A2, A10, A30+31, B13, B15 and negatively associated with HLA-A28, B46. There is a significant difference of HLA-Ⅰ antigens in familial patients, non-familial patients and different clinical types of vitiligo. These findings support the hypothesis of an immunogenetic mechanism in the pathogenesis of vitiligo. There is a immunogenetic background in patients with vitiligo in the Northern Han Chinese.

Key words: Vitiligo, Histocompatibility antigens classⅠ