中华皮肤科杂志 ›› 2001, Vol. 34 ›› Issue (2): 108-109.

• 论著 • 上一篇    下一篇

寻常型银屑病患者17号染色体上两个等位基因频率的检测

王红1, 刘维达1, 李辉2, 金力2   

  1. 1. 中国医学科学院、中国协和医科大学皮肤病研究所 南京 210042;
    2. 上海复旦大学遗传所
  • 收稿日期:2000-04-28 出版日期:2001-04-15 发布日期:2001-04-15

Identification of Two Microsatellite DNA Markers (Shot Tendem Repeats) on Chormosome 17 in Patients with Psoriasis Vulgaris

WANG Hong1, LIU Weida1, LI Hui2   

  1. Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing 210042, China
  • Received:2000-04-28 Online:2001-04-15 Published:2001-04-15

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摘要： 目的 初步探讨2个微卫星标记D17S784及D17S928与寻常型银屑病的相关性。方法 用多重PCR和微卫星荧光标记-半自动基因扫描法以及GenotypeTM软件进行基因分型。结果 银屑病患者与D17S784、D17S928具有显著相关性(P<0.001),这两个微卫星位点的等位基因片段频率分布在银屑病组与健康对照组中差异具有显著性。结论 D17S784与D17S928这2个连续标记可能是寻常型银屑病易感性的候选区域之一。

关键词: 染色体,人,17对, 银屑病

Abstract: Objective To investigate the association of two microsatellite markers, D17S784 and D17S928, with psoriasis vulgaris. Methods Fluorescent multiplex PCR, genescaning and GenotypeTM software were employed to amplify the microsat ellite DNA markers and conduct genotyping. Results The significant association w as found between D17S784, D17S928 and psoriasis vulgaris (P<0.001). The frequencies of their gene fragments were significantly different between patients and healthy controls. Conclusion D17S784 and D17S928 may be the very attractive candidate gene regions for further studies in psoriasis patients.

Key words: Psoriasis, Chromosomes,human,pair 17