中华皮肤科杂志 ›› 2002, Vol. 35 ›› Issue (2): 102-104.

• 论著 • 上一篇    下一篇

寻常型银屑病与单纯疱疹病毒1型相关性的研究

王官清, 张理涛, 徐宏慧, 李远宏, 王雅坤, 高兴华, 赵玉铭, 何春涤, 陈洪铎   

  1. 中国医科大学第一临床学院皮肤科 沈阳 110001
  • 收稿日期:2001-09-05 出版日期:2002-04-15 发布日期:2002-04-15

Study on Association of Psoriasis Vulgaris with Herpes Simplex Virus Type1

WANG Guanqing, ZHANG Litao, XU Honghui, LI Yuanhong, WANG Yakun, GAO Xinghua, ZHAO Yuming, HE Chundi, CHEN Hongduo   

  1. Department of Dermatology, First Hospital of China Medical University, Shenyang 110001, China
  • Received:2001-09-05 Online:2002-04-15 Published:2002-04-15

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摘要： 目的 探讨寻常型银屑病与单纯疱疹病毒1型(HSV-1)的可能相关性。方法 应用PCR法检测患者皮损、外周血单一核细胞(PBMCs)和咽拭子中HSV-1DNA,ELISA法检测患者血清中抗HSV-1的IgM、IgG抗体,并与正常人对照做比较。结果 患者皮损、PBMCs和咽拭子中HSV-1DNA检出率分别为37.5%、18.6%和18.8%,血清中抗HSV-1的IgM、IgG抗体检出率分别为37.2%和53.5%.经χ2检验,患者皮损、PBMCs中HSV-1DNA和血清中IgM抗体检出率显着高于正常人对照,点滴状患者的皮损、PBMCs和咽拭子中HSV-1DNA以及血清中抗HSV-1IgM抗体检出率显着高于斑块状患者。结论 寻常型银屑病尤其是皮损呈点滴状者与HSV-1显着相关,患者可能存在HSV-1的近期感染。

关键词: 单纯疱疹病毒,1型, 银屑病, 聚合酶链反应, 酶联免疫吸附法

Abstract: Objective To analyze the possible association of psoriasis vulgaris with herpes simplex virus type 1 (HSV-1). Methods Polymerase chain reaction was used to detect HSV-1 DNA in lesional skin biopsies, periphery blood mononuclear cells (PBMCs)and throat swabs from patients with psoriasis vulgaris, and ELISA was used to detect IgM and IgG antibodies against HSV-1 in sera from these patients. Results The positive detection rates of HSV-1 DNA in lesional skin biopsies, PBMCs and throat swabs were 37.5%, 18.6%and 18.8%, respectively. Anti HSV-1 IgM and IgG antibodies were positive in 37.2% and 53.5% of serum specimens, respectively. The detection rates of HSV-1 DNA in lesional skin biopsies and PBMCs, and IgM antibody in sera were significantly higher than those in normal controls. In psoriatic patients of guttate type the positive detection rates of HSV-1 DNA and IgM antibody were significantly higher than those in the plaque type. Conclusions There is strong association of psoriasis vulgaris, especially the guttate type, with HSV-1, and there may be recent infection of HSV-1 in these patients.

Key words: Psoriasis, Herpes simplex virus, type 1, Polymerase chain reaction, Enzyme-linked immunosorbent assay