中华皮肤科杂志 ›› 2010, Vol. 43 ›› Issue (12): 873-874.

• 短篇论著 • 上一篇    下一篇

黄褐斑皮损中雌激素受体β的表达分析

唐建兵1,柳大烈2,程飚2,李勤3,余文林2   

  1. 1. 广州军区广州总医院整形美容外科
    2.
    3. 广州军区广州总医院整形外科
  • 收稿日期:2010-04-19 修回日期:2010-07-20 出版日期:2010-12-15 发布日期:2010-12-13
  • 通讯作者: 唐建兵 E-mail:guangdongliuhua@163.com

Expression of estrogen receptor beta in lesions of chloasma

  • Received:2010-04-19 Revised:2010-07-20 Online:2010-12-15 Published:2010-12-13

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摘要：

摘要： 目的 探讨黄褐斑患者病损部位和正常皮肤雌激素受体β（ERβ）分布情况，了解雌激素β在黄褐斑发病中的作用。 方法 应用免疫组化法观察黄褐斑患者色素病损部和正常皮肤的雌激素受体β的表达分布情况，并分析其表达强度与色素的严重程度的相关性。 结果 ERβ在色素斑处表皮层、毛囊外根鞘的细胞核强表达，表皮从基底层向上表达逐渐减弱，在汗腺、皮脂腺、真皮成纤维细胞、血管内皮细胞也有表达。在表皮层中的表达强度与色素的严重程度正相关。 结论 雌激素受体β存在于皮肤及大多数附属器，可能在皮肤老化及皮肤色素沉积的过程中发挥重要作用。

关键词: 黄褐斑, 雌激素受体β

Abstract:

Abstract Objective To investigate the distribution of estrogen receptor β(ERβ) in the skin of of melasma patients, to understand the role of estrogen in the pathogenesis of melasma. Methods The distribution of ERβ was detected by immunohistochemical stain in the pigmented lesion and normal skin in melasma patients，then the correlation of its expression intensity and severity of pigment was analyzed for comparison. Results ERβ expressed strongly in the nucleus of the cell of epidermis and hair follicle’s outer root sheath in pigmentation lesion, and weaken from basal layer of epidermis to superficial. It expressed also in sebaceous glands，sweat glands，dermis fibroblast and vessel endothelial cell. It is positive correlation between the expression ERβ in the epidermis and the severity of pigment. Conclusion ERβ expresses in the skin and its appendant. It may be playing an important role in the process of the skin aging and skin pigmentation.

Key words: estrogen receptor β