中华皮肤科杂志 ›› 2023, Vol. 56 ›› Issue (6): 540-544.doi: 10.35541/cjd.20220807

• 研究报道 • 上一篇    下一篇

丘疹脓疱型玫瑰痤疮患者皮肤高频超声联合彩色多普勒血流成像的特征

米淑宏1    余艳琴2    郝金奇2    李薇1    张杨1    贾喜梅1    黄毓娴1    孙怀玉3    石继海1   

  1. 1内蒙古科技大学包头医学院第一附属医院皮肤性病科，包头  014010；2内蒙古科技大学包头医学院公共卫生学院，包头  014060；3内蒙古科技大学包头医学院第一附属医院超声科，包头  014010
  • 收稿日期:2022-11-14 修回日期:2023-03-22 发布日期:2023-06-05
  • 通讯作者: 石继海；孙怀玉 E-mail:sjh@btmc.edu.cn; sunhuaiyu666@126.com
  • 作者简介:4月录用通知
  • 基金资助:
    内蒙古自治区2021年研究生科研创新项目（S20210169Z）；包头市卫生健康科技计划项目（wsjkkj012）；包头医学院青年科技人才发展计划项目（BYJJ-DXK2022008）

Analysis of imaging characteristics of papulopustular rosacea by high-frequency ultrasound combined with color Doppler flow imaging

Mi Shuhong1, Yu Yanqin2, Hao Jinqi2, Li Wei1, Zhang Yang1, Jia Ximei1, Huang Yuxian1, Sun Huaiyu3, Shi Jihai1   

  1. 1Department of Dermatology, The First Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science and Technology, Baotou 014010, Inner Mongolia, China; 2School of Public Health, Baotou Medical College, Inner Mongolia University of Science and Technology, Baotou 014060, Inner Mongolia, China; 3Department of Ultrasound, The First Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science and Technology, Baotou 014010, Inner Mongolia, China
  • Received:2022-11-14 Revised:2023-03-22 Published:2023-06-05
  • Contact: Shi Jihai; Sun Huaiyu E-mail:sjh@btmc.edu.cn; sunhuaiyu666@126.com
  • Supported by:
    Research and Innovation Project for Postgraduates of Inner Mongolia Autonomous Region in 2021 （S20210169Z）; Baotou Health Science and Technology Plan Project （wsjkkj012）; Baotou Medical College Youth Science and Technology Talent Development Plan Project （BYJJ-DXK2022008）

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摘要： 【摘要】 目的 探讨丘疹脓疱型玫瑰痤疮（PPR）患者皮肤高频超声联合彩色多普勒血流成像的特征。方法 选取2021年8月至2022年8月在内蒙古自治区包头医学院第一附属医院皮肤科门诊就诊的30例PPR患者及30例健康对照，采用22 MHz高频超声联合彩色多普勒血流成像检测面颊部皮肤厚度、回声及血流参数，比较两组人群超声结果。组间比较采用t检验或χ2检验，诊断价值分析采用受试者工作特征（ROC）曲线中的曲线下面积（AUC）分析。结果 病例组男12例，女18例，年龄22 ~ 65（42.3 ± 12.8）岁；对照组男10例，女20例，年龄24 ~ 62（41.0 ± 8.4）岁。病例组面颊部表皮、真皮厚度［（132.64 ± 12.29）、（1 812.29 ± 85.52） μm］均高于对照组［（104.34 ± 14.45）、（1 671.77 ± 146.55） μm，P < 0.05］。病例组面颊部真皮回声形态主要表现为不规则低回声（80%），对照组主要表现为带状中等回声（90%）；病例组较对照组更易出现表皮下低回声带（SLEB）（93.33%比43.33%，P < 0.001）及真皮不规则低回声（80%比10%，P < 0.001）。病例组血流信号丰富者比例（93.3%）高于对照组（10%），血管直径［（1.60 ± 0.42） mm］亦高于对照组［（0.95 ± 0.32） mm］，两组比较，均P < 0.05；收缩期峰值血流速度、血管阻力指数两组差异无统计学意义（P > 0.05）。高频超声与彩色多普勒的定量参数（包括表皮厚度、真皮厚度、血管直径）联合诊断PPR的AUC为0.989（95% CI：0.970 ~ 1.000），敏感度和特异度均为96.7%，均高于单一参数检测。结论 高频超声联合彩色多普勒可对PPR皮损特征及血液流变学进行无创量化监测，对提高PPR诊断的准确性和严重程度评估有一定帮助。

关键词: 红斑痤疮, 诊断, 丘疹脓疱型玫瑰痤疮, 高频超声, 彩色多普勒血流成像

Abstract: 【Abstract】 Objective To investigate imaging characteristics of papulopustular rosacea （PPR） by high-frequency ultrasound combined with color Doppler flow imaging. Methods From August 2021 to August 2022, 30 patients with PPR were enrolled from the Department of Dermatology, the First Affiliated Hospital of Baotou Medical College in the Inner Mongolia Autonomous Region, and 30 healthy volunteers served as controls. The 22-MHz high-frequency ultrasound combined with color Doppler blood flow imaging was performed to measure the skin thickness, echo and blood flow parameters at the cheek, and the ultrasound results were compared between the two groups. Comparisons between groups were conducted by using t test or chi-square test. The diagnostic value was analyzed using the area under the curve （AUC） in the receiver operating characteristic （ROC） curve. Results In the case group, there were 12 males and 18 females, and their ages ranged from 22 to 65 years （42.3 ± 12.8 years）; in the control group, there were 10 males and 20 females, and their ages ranged from 24 to 62 years （41.0 ± 8.4 years）. The epidermal and dermal thicknesses at the cheek were significantly higher in the case group （132.64 ± 12.29 μm, 1 812.29 ± 85.52 μm, respectively） than in the control group （104.34 ± 14.45 μm, 1 671.77 ± 146.55 μm, respectively, both P < 0.05）. High-frequency ultrasound images showed that the case group was mainly characterized by irregular hypoechoic areas in the cheek dermis （80%）, while banded moderately echoic areas were common in the cheek dermis in the control group （90%）; subepidermal low-echogenic bands and dermal irregular hypoechoic areas were more likely to appear in the case group than in the control group （93.33% vs. 43.33%, 80% vs. 10%, respectively, both P < 0.001）. Compared with the control group, the case group showed a significantly increased proportion of patients with abundant blood flow signals （93.3% vs. 10%, P < 0.05）, and significantly increased blood vessel diameters （1.60 ± 0.42 mm vs. 0.95 ± 0.32 mm, P < 0.05）; there was no significant difference in peak systolic blood flow velocity and vascular resistance index between the two groups （both P > 0.05）. The AUC of high-frequency ultrasound combined with color Doppler flow imaging quantitative parameters （including epidermal thicknesses, dermal thicknesses, and blood vessel diameters） was 0.989 （95% CI: 0.970 - 1.000） for the diagnosis of PPR, and the sensitivity and specificity were both 96.7%, which were higher than those of single parameter-based diagnostic model. Conclusion High-frequency ultrasound combined with color Doppler flow imaging can help improve the accuracy of the diagnosis of PPR, by accurately and non-invasively measuring skin thickness and blood flow parameters.

Key words: Rosacea, Diagnosis, Papulopustular rosacea, High-frequency ultrasound, Color Doppler flow imaging

引用本文

米淑宏 余艳琴 郝金奇 李薇 张杨 贾喜梅 黄毓娴 孙怀玉 石继海. 丘疹脓疱型玫瑰痤疮患者皮肤高频超声联合彩色多普勒血流成像的特征[J]. 中华皮肤科杂志, 2023,56(6):540-544. doi:10.35541/cjd.20220807

Mi Shuhong, Yu Yanqin, Hao Jinqi, Li Wei, Zhang Yang, Jia Ximei, Huang Yuxian, Sun Huaiyu, Shi Jihai. Analysis of imaging characteristics of papulopustular rosacea by high-frequency ultrasound combined with color Doppler flow imaging[J]. Chinese Journal of Dermatology, 2023, 56(6): 540-544.doi:10.35541/cjd.20220807