中华皮肤科杂志 ›› 2022, Vol. 55 ›› Issue (12): 1068-1072.doi: 10.35541/cjd.20220019

• 论著 • 上一篇    下一篇

2010—2019年吉林省某三甲医院儿童和成人孢子丝菌病的临床特征比较

姚蕾1    曲芯瑶2    宋洋1    崔岩1    李珊山1   

  1. 1吉林大学第一医院皮肤性病科，长春  130021；2长春中医药大学附属医院药物临床试验办公室，长春  130021
  • 收稿日期:2022-01-10 修回日期:2022-08-09 发布日期:2022-12-05
  • 通讯作者: 崔岩；李珊山 E-mail:supermandsdzam@jlu.edu.cn
  • 基金资助:
    国家自然科学基金（82073454）；吉林省中医药科技项目（2021042）；吉林省直卫生专项项目（JLSWSRCZX2020-007）

Comparison of clinical characteristics of sporotrichosis between children and adults in a third-grade class-A hospital in Jilin province from 2010 to 2019

Yao Lei1, Qu Xinyao2, Song Yang1, Cui Yan1, Li Shanshan1   

  1. 1Department of Dermatology and Venereology, The First Hospital of Jilin University, Changchun 130021, China; 2Department of Drug Clinical Trial, The Affiliated Hospital to Changchun University of Chinese Medicine, Changchun 130021, China
  • Received:2022-01-10 Revised:2022-08-09 Published:2022-12-05
  • Contact: Cui Yan; Li Shanshan E-mail:supermandsdzam@jlu.edu.cn
  • Supported by:
    National Natural Science Foundation of China （82073454）; Administration of Traditional Chinese Medicine of Jilin Province Funded Project （2021042）; The Finance Department Health Special Project of Jilin Province （JLSWSRCZX2020-007）

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摘要： 【摘要】 目的 比较2010—2019年吉林大学第一医院确诊的儿童和成人孢子丝菌病的临床特征差异。方法 回顾性分析2010年1月1日至2019年12月31日吉林大学第一医院皮肤科3 124例孢子丝菌病患者的临床资料，其中儿童（< 18岁）911例，成人（≥ 18岁）2 213例。所有患者均经皮损真菌培养确诊为孢子丝菌病。采用χ2检验比较儿童与成人孢子丝菌病的临床特征差异。结果 911例儿童患者中，男女比例为1.4∶1，720例（79.0%）发生于寒冷季节（1 - 3月及10 - 12月），790例（86.7%）为皮肤固定型孢子丝菌病，835例（91.7%）皮损发生于面部。2 213例成人患者中，男女比例为1∶2.5，1 450例（65.5%）发生于寒冷季节，1 523例（68.8%）为皮肤固定型孢子丝菌病，1 090例（49.3%）皮损累及四肢，975例（44.1%）累及面部。儿童孢子丝菌病在寒冷季节发病的比例明显高于成人（χ2 = 55.55，P < 0.001），皮肤固定型孢子丝菌病比例亦显著高于成人（χ2 = 107.55，P < 0.001）。两组皮损分布差异有统计学意义（χ2 = 599.91，P < 0.001）。结论 儿童与成人孢子丝菌病的流行病学特征和临床表现存在差异。

关键词: 孢子丝菌病, 儿童, 成年人, 流行特征, 临床表现

Abstract: 【Abstract】 Objective To compare clinical characteristics of sporotrichosis between children and adults in a third-grade class-A hospital in Jilin province during 2010—2019. Methods Clinical data were collected from 3 124 patients with sporotrichosis in Department of Dermatology, The First Hospital of Jilin University from January 1, 2010 to December 31, 2019, and retrospectively analyzed. There were 911 children aged < 18 years and 2 213 adults aged ≥ 18 years. All the patients were confirmedly diagnosed with sporotrichosis by fungal culture of skin lesions. Chi-square test was used to compare clinical characteristics of sporotrichosis between children and adults. Results Among the 911 children, the male-to-female ratio was 1.4 ∶1; 720 （79.0%） developed sporotrichosis in cold seasons （January -March and October-December）, 790 （86.7%） were diagnosed with fixed cutaneous sporotrichosis, and 835 （91.7%） presented with skin lesions on the face. Among the 2 213 adult patients, the male-to-female ratio was 1∶2.5; 1 450 （65.5%） developed sporotrichosis in cold seasons, 1 523 （68.8%） were diagnosed with fixed cutaneous sporotrichosis; skin lesions mostly occurred on the extremities （1 090 cases, 49.3%） and face （975 cases, 44.1%）. The proportion of patients developing sporotrichosis in cold seasons was significantly higher in children than in adults （χ2 = 55.55, P < 0.001）, and the proportion of fixed cutaneous sporotrichosis was also significantly higher in children than in adults （χ2 = 107.55, P < 0.001）. In addition, the distribution of skin lesions significantly differed between the children and adults （χ2 = 599.91, P < 0.001）. Conclusion The epidemiological characteristics and clinical manifestations of sporotrichosis markedly differed between children and adults.

Key words: Sporotrichosis, Child, Adult, Epidemiological characteristics, Clinical manifestations