中华皮肤科杂志 ›› 2007, Vol. 40 ›› Issue (1): 31-33.

• 论著 • 上一篇    下一篇

皮肌炎/多发性肌炎伴恶性肿瘤45例分析

陈小红1, 杨建1, 杨荣明2, 韩建德1   

  1. 1. 中山大学附属第一医院皮肤科 广州 510080;
    2. 江西上犹县皮肤性病防治所
  • 收稿日期:2006-04-10 出版日期:2007-01-15 发布日期:2007-01-15
  • 通讯作者: 韩建德,email:hanjd_gzb@21cn.net E-mail:hanjd_gzb@21cn.net

Dermatomyositis and polymyositis associated with malignancy：a retrospective analysis of 45 cases

CHEN Xiao-hong1, YANG Jian1, YANG Rong-ming2, HAN Tan-de1   

  1. Department of Dermatology, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China
  • Received:2006-04-10 Online:2007-01-15 Published:2007-01-15

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摘要： 目的 分析皮肌炎/多发性肌炎伴发恶性肿瘤患者的临床情况.方法 回顾性分析我院1991-2005年间45例皮肌炎/多发性肌炎伴发恶性肿瘤患者,分析其临床特点及肿瘤相关因素.结果 313例皮肌炎l多发性肌炎患者中45例(14.38%)伴发恶性肿瘤,伴发的肿瘤主要为鼻咽癌、肺癌、乳腺癌,69%患者恶性肿瘤发现于皮肌炎的诊断之时.伴发肿瘤的高危因子包括皮肌炎的发病年龄晚(>40岁)(P=0.0047,OR=0.186)及病程短(<1年)(P=0.0033,OR=3.884).结论 皮肌炎/多发性肌炎常伴发恶性肿瘤,所合并肿瘤的类型广泛,但以鼻咽癌、肺癌、乳腺癌等为主.对于年龄>40岁、病程<1年的患者,应进行相关检查及监测以排除可能合并的恶性肿瘤.

关键词: N-乙酰氨基葡萄糖, 成纤维细胞, 透明质酸, 透明质酸合成酶, 皮肌炎, 鼻咽肿瘤, 肺肿瘤, 乳腺肿瘤, 副肿瘤综合征

Abstract: Objective To investigate the clinical features of dermatomyositis and polymyositis associated with malignancy. Methods A retrospective study was performed of 313 patients with a diagnosis of dermatomyositis and polymyositis admitted to the First Affiliated Hospital of Sun Yat-sen University over a period of 15 years. The clinical characteristics and risk factors of cases associated with malignancy were analyzed. Results Among these 313 patients with dermatomyositis and polymyositis, the incidence of malignancy was 14.38%(45/313).Of the 45 patients with malignancy, 69%(31/45)cancers were diagnosed at the same time as dermatomyositis and polymyositis, and the most common malignancies were nasopharyngeal carcinoma, lung cancer, and breast cancer. Statistical analyses revealed that the high risk factors of concomitant malignancy included an onset in older age(>40 years)(P=0.0047, OR=0.186)and a shorter disease history(<1 year)(P=0.0033, OR=3.884). Conclusions These results provide evidence that dermatomyositis and polyrnyositis are frequently associated with a wide variety of cancers, particularly carcinoma of nasopharynx, lung, and breast. Patients over 40 years of age or with a disease history of less than 1 year should be screened for possible associated malignancy.

Key words: Dermatomyositis, Nasopharyngeal neoplasms, Lung neoplasms, Breast neoplasms;Syndromes, paraneoplastic