中华皮肤科杂志 ›› 2021, Vol. 54 ›› Issue (2): 174-178.doi: 10.35541/cjd.20190860
刘凤洁 涂平 汪旸
收稿日期:
2019-08-29
修回日期:
2020-07-15
发布日期:
2021-01-29
通讯作者:
汪旸
E-mail:yangwang_dr@bjmu.edu.cn
Liu Fengjie, Tu Ping, Wang Yang
Received:
2019-08-29
Revised:
2020-07-15
Published:
2021-01-29
Contact:
Wang Yang
E-mail:yangwang_dr@bjmu.edu.cn
摘要: 【摘要】 蕈样肉芽肿是原发皮肤T细胞淋巴瘤中最常见的类型,其发病机制仍然不清楚。研究显示,蕈样肉芽肿存在高频染色体片段拷贝数变异,如染色体7q、1q、17q的扩增和9p21、10q、17p的缺失,导致相应区域上原癌基因扩增和抑癌基因丢失,从而促进肿瘤的发生发展。同时蕈样肉芽肿中存在低频单核苷酸变异,这些变异基因主要集中在细胞周期调控、细胞凋亡、染色质重塑以及T细胞活化相关的通路上。蕈样肉芽肿很少有发生基因融合变异的报道。另外,部分蕈样肉芽肿病例会发生大细胞转化,往往预示疾病进展及药物抵抗等不良预后。总之,蕈样肉芽肿是一种具有高度分子遗传学异质性的复杂疾病,未来还需要更广泛深入的机制研究。
刘凤洁 涂平 汪旸. 蕈样肉芽肿分子遗传学致病机制的研究进展[J]. 中华皮肤科杂志, 2021,54(2):174-178. doi:10.35541/cjd.20190860
Liu Fengjie, Tu Ping, Wang Yang. Molecular genetic pathogenesis of mycosis fungoides[J]. Chinese Journal of Dermatology, 2021, 54(2): 174-178.doi:10.35541/cjd.20190860
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