Abstract:

Cang Tian, Wang Baoxi, Gong Xiangdong, Li Qi, Xu Haoxiang, Liu Yi Department of Dermatology, Hospital of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing 210042, China （the current affiliation of the second author was Department of Dermatology， Plastic Surgery Hospital， Chinese Academy of Medical Sciences and Peking Union Medical College， Beijing 100144， China） Corresponding author: Wang Baoxi, Email: tiantiancang@126.com 【Abstract】 Objective To assess the association between tumor necrosis factor α （TNF-α）-308 G/A polymorphism and the susceptibility to acne vulgaris by using a meta-analysis. Methods Relevant literature was searched in the PubMed （1948-August 20, 2015）, Embase （1974-August 20, 2015） and CNKI （1994-August 20, 2015） databases. According to the inclusion and exclusion criteria, case-control studies on the association between the TNF-α-308 G/A polymorphism and acne vulgaris were selected. Then, the quality of studies was evaluated, data were extracted, and statistical analysis was done by using Stata 12.0 software. Results Finally, 7 eligible studies were included in this meta-analysis, which comprised 986 patients with acne vulgaris and 1 074 healthy controls. No significant association was observed between the TNF-α-308 G/A polymorphism and acne vulgaris. Conclusion There is no significant association between TNF-α-308 G/A polymorphism and acne vulgaris.