脓疱性银屑病的遗传学研究进展

摘要/Abstract

摘要：

脓疱性银屑病是一种并不少见的炎症性皮肤病，临床以突发泛发性红斑与无菌性脓疱伴寒战高热、中性粒细胞增高及C反应蛋白增高为特征。该病常反复发作，对患者的生活质量造成极大影响。近年来陆续发现，IL36RN、CARD14、AP1S3基因突变与脓疱性银屑病的发生有关，随之出现了一些新的治疗方法。本文综述脓疱性银屑病遗传学研究的最新进展。

Abstract:

Li Zhongtao, Wang Sheng Department of Dermatology and Venereology, West China Hospital, Sichuan University, Chengdu 610041, China Corresponding author: Wang Sheng, Email: wangsheng1892@sina.com 【Abstract】 Pustular psoriasis is not a rare inflammatory skin disease, and is characterized by sudden onset of generalized erythema and sterile pustules complicated by chills, high fever, neutrophilia and elevated levels of C-reactive protein. Due to frequent recurrence, it greatly impacts the quality of life in patients. Recently, it has been gradually found that IL36RN, CARD14 and AP1S3 mutations are associated with the occurrence of pustular psoriasis, and accordingly some new therapeutic approaches have emerged. This review summarizes recent advances in genetics of pustular psoriasis.

李仲桃汪盛. 脓疱性银屑病的遗传学研究进展[J]. 中华皮肤科杂志, 2016, 49(11): 827-830.

Zhong-Tao LI Sheng WANG. Pustular psoriasis: an update on genetics[J]. Chinese Journal of Dermatology, 2016, 49(11): 827-830.

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