中华皮肤科杂志 ›› 2014, Vol. 47 ›› Issue (7): 506-508.

• 研究报道 • 上一篇    下一篇

大疱性类天疱疮患者皮损中CXCR5的表达及意义

杨敏1,2,朱英华2,崔红艳1,赵岩2,王绘翔2   

  1. 1.
    2. 大连市皮肤病医院
  • 收稿日期:2013-06-26 修回日期:2013-09-06 发布日期:2014-07-01
  • 通讯作者: 朱英华 E-mail:zyh-office@163.com

Expression of CXC chemokine receptor 5 in skin lesions of bullous pemphigoid and its significance

  • Received:2013-06-26 Revised:2013-09-06 Published:2014-07-01

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摘要： 目的 检测滤泡辅助性T细胞（Tfh）趋化因子受体5（CXCR5）在大疱性类天疱疮患者皮损中的表达，分析和探讨CXCR5在大疱性类天疱疮发病机制中的作用。 方法 应用免疫组化法检测16例大疱性类天疱疮患者皮损及10例健康人皮肤中CXCR5的表达。 结果 CXCR5在健康人皮肤表达于基底细胞层，主要表达于细胞质、细胞膜处；在大疱性类天疱疮皮损中表达于基底细胞层与棘细胞层。CXCR5在健康人皮肤中阳性细胞表达均数为11.16 ± 4.47，在大疱性类天疱疮患者皮损中为35.70 ± 12.20，两组差异有统计学意义（t = 6.07，P < 0.01）。 结论 CXCR5可能参与大疱性类天疱疮的发病。

关键词: 类天疱疮，大疱性, 受体，趋化因子, 滤泡性T辅助细胞

Abstract: Yang Min*, Zhu Yinghua, Cui Hongyan, Zhao Yan, Wang Huixiang. *Dalian Medical University, Dalian 116021, China Corresponding author: Zhu Yinghua, Email: zyh-office@163.com 【Abstract】 Objective To study the role of CXC chemokine receptor 5 （CXCR5） in the pathogenesis of bullous pemphigoid （BP） by detecting the expression of CXCR5 on follicular helper T （Tfh） cells in skin lesions of BP. Methods An immunohistochemical procedure was used to detect CXCR5 expression in biopsy specimens from skin lesions of 16 patients with BP and normal skin of 10 healthy individuals. Results CXCR5 was mainly expressed in the cytoplasm and membrane of Tfh cells in the basal cell layer of normal skin as well as in both basal cell layer and prickle cell layer of BP lesions. The number of CXCR5-positive cells per high power field （× 400） was 11.16 ± 4.47 in normal skin specimens, significantly lower than that in lesional skin specimens （35.70 ± 12.20, t = 6.07, P < 0.01）. Conclusion CXCR5 may be involved in the pathogenesis of BP.

Key words: Pemphigoid, bullous, Receptors, chemokine, Follicular helper T lymphocytes

引用本文

杨敏 朱英华 崔红艳 赵岩 王绘翔. 大疱性类天疱疮患者皮损中CXCR5的表达及意义[J]. 中华皮肤科杂志, 2014,47(7):506-508. doi: