中华皮肤科杂志 ›› 2010, Vol. 43 ›› Issue (7): 452-454.

• 论著 • 上一篇    下一篇

632例皮肤恶性肿瘤及癌前病变临床分析

黄远深1,李航2,涂平2,陈喜雪3,杨淑霞2,武玲慎3,赵俊郁4,李雪迎5   

  1. 1. 北京大学第一医院皮肤与性病科（杂志寄给李航转）
    2. 北京大学第一医院皮肤科
    3. 北京大学第一医院皮肤性病科
    4. 北京医科大学第一医院皮肤科
    5.
  • 收稿日期:2009-11-23 修回日期:2010-01-23 出版日期:2010-07-15 发布日期:2010-07-13
  • 通讯作者: 黄远深 E-mail:isresident@126.com
  • 基金资助:

    卫生部部属(管)医院临床学科重点项目

Skin cancer and precancerous skin lesions: clinical analysis of 632 cases

  • Received:2009-11-23 Revised:2010-01-23 Online:2010-07-15 Published:2010-07-13

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摘要：

目的 探讨皮肤恶性肿瘤的临床特点。方法 回顾2005—2008年病理诊断皮肤恶性肿瘤及癌前病变的病例资料，重新阅片确认肿瘤诊断和病理亚型分型后，利用统计软件进行分析。结果 基底细胞癌及原位和侵袭性鳞状细胞癌最多见，分别占总病例数的29.3%及24.2%。在所研究病例中， > 60岁发病者占55.4%，35 ~ 59岁发病比例达到34.3%，青少年患者比例为10.3%。Paget病临床诊断与病理诊断的符合率接近90.0%，但其他常见皮肤恶性肿瘤及癌前病变临床与病理的符合率仅在70.0%左右。结论 在皮肤恶性肿瘤及癌前病变中，头面部皮肤肿瘤及癌前病变病例明显多于其他部位。中青年患者不仅在皮肤淋巴瘤相关肿瘤病例中多见，而且在上皮来源的皮肤恶性肿瘤及黑素瘤病例中占有显著比例。

关键词: 皮肤恶性肿瘤及癌前病变, 基底细胞癌, 鳞状细胞癌, Paget病, 日光性角化

Abstract:

Objective To investigate the clinical features of skin cancer. Methods Clinical data of skin cancer and precancerous skin lesions confirmed pathologically from 2005 to 2008 in Peking University First Hospital were retrospectively analyzed by using statistical methods. Results A total of 632 cases of skin cancer and precancerous skin lesions were studied. The most common skin cancer was basal cell carcinoma and squamous cell carcinoma （invasive and in situ） which accounted for 29.3% and 24.2%, respectively. The average age at onset was older than 60 years in 55.4% of the patients, between 35 and 59 years in 34.3%, younger than 35 years in 10.3%. The concordance between clinical and pathological diagnosis reached nearly 90.0% for Paget′s disease, 70.0% for other common skin cancer and precancerous skin lesions. Conclusions Skin cancer and precancerous skin lesions have a predilection for scalp and face. Patients aged from 35 to 59 years account for a significant proportion not only in cutaneous lymphoma but also in melanoma and epithelium-derived nonmelanoma skin cancer.

Key words: Skin cancer and precancerous skin lesions, Basal cell carcinoma, Squamous cell carcinoma, Paget's disease, Actinic keratosis