中华皮肤科杂志 ›› 2010, Vol. 43 ›› Issue (6): 431-432.

• 病例报告 • 上一篇    下一篇

副肿瘤性天疱疮伴发滤泡性淋巴瘤一例

周城1,孙珮纹2,陈雪2,金江3,张建中3   

  1. 1. 北京大学人民医院
    2.
    3. 北京大学人民医院皮肤科
  • 收稿日期:2009-09-14 修回日期:2010-01-15 出版日期:2010-06-15 发布日期:2010-06-08
  • 通讯作者: 周城 E-mail:chengzhou@live.cn

A case of paraneoplastic pemphigus complicated by follicular lymphoma

  • Received:2009-09-14 Revised:2010-01-15 Online:2010-06-15 Published:2010-06-08
  • Contact: Cheng ZHOU E-mail:chengzhou@live.cn

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摘要：

报告1例伴发滤泡性淋巴瘤的副肿瘤性天疱疮。患者女，51岁，口腔、外阴疼痛性糜烂、溃疡伴全身皮疹2个月，既往全身淋巴结肿大1年。皮肤组织病理学检查示表皮可见棘细胞松解，表皮内裂隙，散在坏死红染的角质形成细胞，基底细胞液化变性及真皮浅层较致密淋巴细胞浸润。淋巴结病理检查示：非霍奇金淋巴瘤，WHO分类：滤泡性淋巴瘤，1级。

关键词: 副肿瘤性, 天疱疮, 淋巴瘤

Abstract:

A case of paraneoplastic pemphigus was reported. The 51-year-old woman complained of painful extensive erosions, ulcerations in the mucosa of entire oral cavity, tongue, lips and genitalia with generalized eruptions for two weeks. She had suffered from diffuse lymph node enlargement for 1 year. The histopathology of skin lesions showed acantholysis, keratinocyte necrosis and vacuolar interface dermatitis suggested paraneoplastic pemphigus. Lymph node biopsy revealed non Hodgkin lymphoma, follicular lymphoma, grade 1, in the WHO Classification System.

Key words: paraneoplastic, pemphigus, lymphoma