关键词: 线状皮肤型红斑狼疮, 临床表现, 组织病理

Abstract:

Objective To summarize the clinical and histological features of linear cutaneous lupus erythematosus （LCLE）. Methods Six cases of LCLE were analyzed retrospectively. Results LCLE was often clinically characterized by unilateral, zonal or linear, dark-erythematous patches with telangiectasia, and some lesions were covered with adherent scales. Histologically, there were patchy perivascular and periadnexal lymphoid inflammatory infiltrate occurring in the superficial and deep dermis. Some cases were pathologically manifested by parakeratosis of superficial dermis, follicular plugging and hydropic degeneration of the basal layer of the epidermis, which was characteristic of discoid lupus erythematosus. The preferred treatment was chloroquine for LCLE. Low dose of corticosteroids were recommended for widespread lesions, especially for those pathologically manifested by lymphocyte infiltrates in the lower dermis and fat tissue. Conclusion The diagnosis of LCLE should be based on clinical and histopathological manifestations.

Key words: linear cutaneous lupus erythematosus, clinical manifestations, histopathology