中华皮肤科杂志 ›› 2010, Vol. 43 ›› Issue (3): 202-202.

• 短篇论著 • 上一篇    下一篇

新生儿期发病的白癜风与遗传因素关系的探讨

桂金萍   

  1. 湖北省襄樊市中医院皮肤科
  • 收稿日期:2009-04-13 修回日期:2009-11-16 出版日期:2010-03-15 发布日期:2012-03-31
  • 通讯作者: 桂金萍 E-mail:guijinping@126.com

Association of neonatal-onset vitiligo to genetic factors

  • Received:2009-04-13 Revised:2009-11-16 Online:2010-03-15 Published:2012-03-31

摘要:

[摘要] 目的 探讨遗传因素在新生儿期发病白癜风中的作用。方法 2002-2008年12月对我院白癜风专病门诊确诊的42例新生儿期(出生或出生几天后)即发现有白癜风的患者及其家系进行了详细的问卷调查与分析。结果 42例中男20例;女22例,有阳性家族史者17例占40.48%;在17例家系中,寻常型13例占30.95%、节段型4例占9.52%。一级、二级、三级、四级亲属患病率,分别为26.19%、33.33%、14.29%、11.90%。在家族连续几代发病中,其发病年龄逐渐提前,并可发生在相同年龄段和相似部位。结论 白癜风发病存在先天因素,提示遗传因素可能参与白癜风先天发病。

关键词: 遗传

Abstract:

[Abstract] Objective To analyze the genetic factors in vitiligo in newborn. Methods Forty-two cases of vitiligo in newborn and their pedigrees were studied. Results Among the 42 probands, 20 were male, and 22 were female; 17(40.48%) of them had a family history of vitiligo. Among the 17 familial vitiligo, 13(30.95%) of them were vitiligo vulgaris, 4 (9.52%) of them were segmental vitiligo. Among relatives of these patients, there were 26.19%, 33.33%, 14.29% and 11.90% percent of members with vitiligo in their first, second, third and fourth-degree relatives respectively. The age of onset was observed to be antedated among some of the families. Conclusion Genetic factors play an important roal in vitiligo in newborn.

Key words: Heredity