雄激素性秃发的发病机制

doi:10.3760/cma.j.issn.0412-4030.2019.03.014

中华皮肤科杂志 ›› 2019, Vol. 52 ›› Issue (3): 208-210.doi: 10.3760/cma.j.issn.0412-4030.2019.03.014

雄激素性秃发的发病机制

汤顺利方红

浙江大学医学院附属第一医院皮肤科，杭州 310003

收稿日期:2018-03-12 修回日期:2018-12-31 发布日期:2019-03-04
通讯作者: 方红 E-mail:fanghongzy@sina.com
基金资助:
国家自然科学基金（81673045）

Pathogenesis of androgenetic alopecia

Tang Shunli, Fang Hong

Department of Dermatology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China

Received:2018-03-12 Revised:2018-12-31 Published:2019-03-04
Contact: Fang Hong E-mail:fanghongzy@sina.com
Supported by:
National Natural Science Foundation of China （81673045）

摘要/Abstract

摘要： 【摘要】雄激素性秃发（AGA）是最常见的一种非瘢痕性脱发类型。研究提示，AGA的发病机制涉及遗传背景、性激素代谢异常与毛囊微型化、毛囊微环境炎症反应以及环境因素等多个方面，其中遗传易感性是造成AGA个体发病差异最重要的因素，性激素代谢异常和/或毛囊微环境炎症反应诱发的毛囊微型化则是AGA发病的最后环节。

关键词: 秃发；皮肤疾病, 遗传性；雄激素类；雄激素性秃发；微炎症

Abstract: 【Abstract】 Androgenetic alopecia （AGA） is the most common type of non-cicatricial alopecia. Many researches have indicated that the pathogenesis of AGA involves genetic background, abnormal metabolism of sex hormones and follicle miniaturization, hair follicle microinflammation and environmental factors. Among them, genetic susceptibility is the most important factor for the individual difference of AGA, and follicle miniaturization induced by abnormal sex hormone metabolism and/or hair follicle microinflammation is the last step in the occurrence of AGA.

Key words: Alopecia, Skin diseases, genetic, Androgens, Androgenetic alopecia, Microinflammation

中图分类号:

汤顺利方红. 雄激素性秃发的发病机制[J]. 中华皮肤科杂志, 2019,52(3):208-210. doi:10.3760/cma.j.issn.0412-4030.2019.03.014

Tang Shunli, Fang Hong. Pathogenesis of androgenetic alopecia[J]. Chinese Journal of Dermatology, 2019, 52(3): 208-210.doi:10.3760/cma.j.issn.0412-4030.2019.03.014

参考文献 31

［1］	Wang TL, Zhou C, Shen YW, et al. Prevalence of androgenetic alopecia in China: a community⁃based study in six cities［J］. Br J Dermatol, 2010,162（4）:843⁃847. doi: 10.1111/j.1365⁃2133. 2010.09640.x.
［2］	Nyholt DR, Gillespie NA, Heath AC, et al. Genetic basis of male pattern baldness［J］. J Invest Dermatol, 2003,121（6）:1561⁃1564. doi: 10.1111/j.1523⁃1747.2003.12615.x.
［3］	Pirastu N, Joshi PK, de Vries PS, et al. GWAS for male⁃pattern baldness identifies 71 susceptibility loci explaining 38 of the risk［J］. Nat Commun, 2017,8（1）:1584. doi: 10.1038/s41467⁃017⁃01490⁃8.
［4］	Liu F, Hamer MA, Heilmann S, et al. Prediction of male⁃pattern baldness from genotypes［J］. Eur J Hum Genet, 2016,24（6）:895⁃902. doi: 10.1038/ejhg.2015.220.
［5］	Marcińska M, Pospiech E, Abidi S, et al. Evaluation of DNA variants associated with androgenetic alopecia and their potential to predict male pattern baldness［J/OL］. PLoS One, 2015,10（5）:e0127852. ［2018⁃03⁃10］. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0127852. doi: 10.1371/journal.pone.0127852.
［6］	Yim E, Nole KL, Tosti A. 5α⁃Reductase inhibitors in androgenetic alopecia［J］. Curr Opin Endocrinol Diabetes Obes,2014,21（6）:493⁃498. doi: 10.1097/MED.0000000000000112.
［7］	Azzouni F, Godoy A, Li Y, et al. The 5 alpha⁃reductase isozyme family: a review of basic biology and their role in human diseases［J］. Adv Urol, 2012,2012:530121. doi: 10.1155/2012/530121.
［8］	Sawaya ME, Price VH. Different levels of 5 alpha⁃reductase type I and II, aromatase, and androgen receptor in hair follicles of women and men with androgenetic alopecia［J］. J Invest Dermatol, 1997,109（3）:296⁃300.
［9］	Lee MJ, Cha HJ, Lim KM, et al. Analysis of the microRNA profile of normal human dermal papilla cells treated with 5α⁃dihydrotestosterone［J］. Mol Med Rep, 2015,12（1）:1205⁃1212. doi: 10.3892/mmr.2015.3478.
［10］	Zhao J, Harada N, Okajima K. Dihydrotestosterone inhibits hair growth in mice by inhibiting insulin⁃like growth factor⁃I production in dermal papillae［J］. Growth Horm IGF Res, 2011,21（5）:260⁃267. doi: 10.1016/j.ghir.2011.07.003.
［11］	Headington JT. Transverse microscopic anatomy of the human scalp. A basis for a morphometric approach to disorders of the hair follicle［J］. Arch Dermatol, 1984,120（4）:449⁃456.
［12］	Jahoda CA. Cellular and developmental aspects of androgenetic alopecia［J］. Exp Dermatol, 1998,7（5）:235⁃248.
［13］	Sinclair R, Torkamani N, Jones L. Androgenetic alopecia: new insights into the pathogenesis and mechanism of hair loss［J］. F1000Res, 2015,4（F1000 Faculty Rev）:585. doi: 10.12688/f1000 research.6401.1.
［14］	Futterweit W, Dunaif A, Yeh HC, et al. The prevalence of hyperandrogenism in 109 consecutive female patients with diffuse alopecia［J］. J Am Acad Dermatol, 1988,19（5 Pt 1）:831⁃836.
［15］	Schmidt JB, Lindmaier A, Trenz A, et al. Hormone studies in females with androgenic hairloss［J］. Gynecol Obstet Invest, 1991,31（4）:235⁃239. doi: 10.1159/000293166.
［16］	Levy LL, Emer JJ. Female pattern alopecia: current perspec⁃tives［J］. Int J Womens Health, 2013,5:541⁃556.
［17］	Sánchez P, Serrano⁃Falcón C, Torres JM, et al. 5α⁃Reductase isozymes and aromatase mRNA levels in plucked hair from young women with female pattern hair loss［J］. Arch Dermatol Res, 2018,310（1）:77⁃83. doi: 10.1007/s00403⁃017⁃1798⁃0.
［18］	Miller JA, Darley CR, Karkavitsas K, et al. Low sex⁃hormone binding globulin levels in young women with diffuse hair loss［J］. Br J Dermatol, 1982,106（3）:331⁃336.
［19］	Zhang Y, Xu J, Jing J, et al. Serum levels of androgen⁃associated hormones are correlated with curative effect in androgenic alopecia in young men［J］. Med Sci Monit, 2018,24:7770⁃7777. doi: 10.12659/MSM.913116.
［20］	Whiting DA. Diagnostic and predictive value of horizontal sections of scalp biopsy specimens in male pattern androgenetic alopecia［J］. J Am Acad Dermatol, 1993,28（5 Pt 1）:755⁃763.
［21］	Ramos PM, Brianezi G, Martins AC, et al. Apoptosis in follicles of individuals with female pattern hair loss is associated with perifollicular microinflammation［J］. Int J Cosmet Sci, 2016,38（6）:651⁃654. doi: 10.1111/ics.12341.
［22］	Piérard⁃Franchimont C, De Doncker P, Cauwenbergh G, et al. Ketoconazole shampoo: effect of long⁃term use in androgenic alopecia［J］. Dermatology, 1998,196（4）:474⁃477. doi: 10.1159/000017954.
［23］	Aldhalimi MA, Hadi NR, Ghafil FA. Promotive effect of topical ketoconazole, minoxidil, and minoxidil with tretinoin on hair growth in male mice［J］. ISRN Pharmacol, 2014,2014:575423. doi: 10.1155/2014/575423.
［24］	Mahé YF, Michelet JF, Billoni N, et al. Androgenetic alopecia and microinflammation［J］. Int J Dermatol, 2000,39（8）:576⁃584.
［25］	Sadgrove NJ. The new paradigm for androgenetic alopecia and plant⁃based folk remedies: 5α⁃reductase inhibition, reversal of secondary microinflammation and improving insulin resistance［J］. J Ethnopharmacol, 2018,227:206⁃236. doi: 10. 1016/j.jep. 2018.09.009.
［26］	Su LH, Chen LS, Chen HH. Factors associated with female pattern hair loss and its prevalence in Taiwanese women: a community⁃based survey［J］. J Am Acad Dermatol, 2013,69（2）:e69⁃e77. doi: 10.1016/j.jaad.2012.09.046.
［27］	Nargis T, Bejai V, Pinto M, et al. Early onset androgenetic alopecia in men and associated risk factors: a hospital based study［J］. Int J Res Dermatol, 2017,3（2）:267⁃271. doi: 10.18203/ issn.2455⁃4529.IntJResDermatol20172209.
［28］	Yang CC, Hsieh FN, Lin LY, et al. Higher body mass index is associated with greater severity of alopecia in men with male⁃pattern androgenetic alopecia in Taiwan: a cross⁃sectional study［J］. J Am Acad Dermatol, 2014,70（2）:297⁃302.e1. doi: 10.1016/ j.jaad.2013.09.036.
［29］	Fortes C, Mastroeni S, Mannooranparampil TJ, et al. The combination of overweight and smoking increases the severity of androgenetic alopecia［J］. Int J Dermatol, 2017,56（8）:862⁃867. doi: 10.1111/ijd.13652.
［30］	Bittencourt C, Teixeira F, Ferraro DA, et al. Non⁃invasive method distinguishes chronic telogen effluvium from mild female pattern hair loss: clinicopathological correlation［J］. Int J Dermatol, 2016,55（7）:e373⁃e379. doi: 10.1111/ijd.13200.
［31］	Iorizzo M, Tosti A. Treatments options for alopecia［J］. Expert Opin Pharmacother, 2015,16（15）:2343⁃2354. doi: 10.1517/1465 6566.2015.1084501.

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雄激素性秃发的发病机制

Pathogenesis of androgenetic alopecia

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