中华皮肤科杂志 ›› 2009, Vol. 42 ›› Issue (9): 596-599.

• 论著 • 上一篇    下一篇

慢性光化性皮炎病情评估及其与光试验关系的研究

黄淳韵1,严淑贤2,廖康煌2,等3   

  1. 1. 上海市复旦大学附属华山医院皮肤科
    2. 上海复旦大学附属华山医院皮肤科
    3. 湖北省中山医院整形美容外科
  • 收稿日期:2008-09-16 修回日期:2008-10-12 出版日期:2009-09-15 发布日期:2012-03-21
  • 通讯作者: 黄淳韵 E-mail:mimiyii@yahoo.com.cn
  • 基金资助:
    无;无

Relationship of severity of chronic actinic dermatitis with photosensitivity profile of patients

  • Received:2008-09-16 Revised:2008-10-12 Online:2009-09-15 Published:2012-03-21

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摘要： 目的　探讨慢性光化性皮炎病情严重程度的评分标准与光试验结果、病程、年龄、初发年龄、既往是否合并其他皮炎湿疹病史的相关性。方法 采取当面询问填写问卷形式，对71例慢性光化性皮炎患者进行病情严重程度评分。集中于2、3月份对患者进行光试验。采用SPSS 11.5进行统计学分析。结果 ①慢性光化性皮炎病情严重程度评分在对 UVA和（或）UVB敏感的不同组别差异有统计学意义（单因素方差分析，F = 10.245，P < 0.01）。②CAD病情轻度组和重度组的UVA-MED值和UVB-MED值的分布差异均有统计学意义（秩和检验，P < 0.01）。③CADSI与UVA-MED值呈负相关性（r = -0.559，P < 0.01），与UVB-MED呈负相关性（r = -0.377，P < 0.01）。④不同治疗组别的UVA-MED值和UVB-MED值分布差异有统计学意义（秩和检验，P < 0.01）。结论 严重程度评分可以用来评价1年内慢性光化性皮炎的病情，UVA-MED值与UVB-MED值在一定程度上可反映慢性光化性皮炎病情严重程度。

关键词: 光过敏疾患, 问卷调查, 损伤严重度评分, 光, 皮肤试验

Abstract: Objective To assess the relationship of disease severity of chronic actinic dermatitis （CAD） to photosensitivity profile, disease course, age, onset age, past history of other disorders such as complicated dermatitis or eczema, of patients. Methods To evaluate the severity of CAD, a questionnaire interview was carried out with 71 outpatients clinically diagnosed as CAD. A CAD severity index （CADSI） was calculated according to the answer of interview. Phototest was carried out from February to March in all patients. Patients were divided into 4 groups based on their sensitivity to UVA and UVB, i.e. insensitive to UVA or UVB, sensitive to UVA only, sensitive to UVB only, sensitive to both UVA and UVB. SPSS 11.5 was used for statistical analysis. Results A significant difference of CADSI was observed among patients with different photosensitivity （F = 10.245, P < 0.01）. The average UVA-minimal erythema dose （MED） and UVB-MED values were 38.5 J/cm2 and 32.9 J/cm2, respectively, in patients with a CADSI of ≤10, significantly higher than those in patients with a CADSI of > 10 （3.9 J/cm2 and 13.4 J/cm2, respectively, both P < 0.01）. CADSI value was negatively correlated with UVA-MED （r = -0.559, P < 0.01） and UVB-MED （r = -0.377, P < 0.01）. Also, there was a significant difference in UVA-MED （χ2 = 26.56, P < 0.01） and UVB-MED （χ2 = 18.22, P < 0.01） among patients receiving different treatment strategies. Conclusions CADSI could be applied to evaluate the severity of CAD in recent one year. UVA-MED and UVB-MED are correlated with the severity of CAD in a degree.