中华皮肤科杂志 ›› 2009, Vol. 42 ›› Issue (7): 500-501.

• 短篇论著 • 上一篇    下一篇

超脉冲CO2点阵激光治疗皮肤光老化的临床观察

李远宏1,张丽1,徐宏慧2,徐天华1,高兴华1,陈洪铎3,等4   

  1. 1. 沈阳 中国医科大学附属第一医院皮肤科
    2. 中国医科大学第一临床医院皮肤科 110001
    3. 沈阳 中国医科大学第一附属医院皮肤科,No.1 Hospital of China Medical University
    4. 湖北省中山医院整形美容外科
  • 收稿日期:2008-06-11 修回日期:2009-03-17 出版日期:2009-07-15 发布日期:2009-07-08
  • 通讯作者: 李远宏
  • 基金资助:

    2007年教育部创新团队基金资助(IRT0760)

Clinical efficacy of ultrapulsed carbon dioxide laser in the treatment of skin photoaging

  • Received:2008-06-11 Revised:2009-03-17 Online:2009-07-15 Published:2009-07-08
  • Contact: yuanhong li

摘要:

目的 观察超脉冲CO2点阵激光治疗面部皮肤光老化的疗效以及安全性。方法 30名中重度光老化患者接受全面部皮肤超脉冲CO2点阵激光单次治疗,只扫描1遍。在治疗前以及随访时(1个月、3个月)进行疗效和副作用的观察。治疗前后测定黑素指数,医生对治疗效果进行综合评估(五级评分法),并由患者进行满意度及副作用评估。 结果 经过单次治疗,额头及颧骨处皮肤的黑素指数显著下降(p<0.001)。不规则色素斑减少,细小以及粗大的皱纹均变浅,面色萎黄改善,弹力增加,毛孔变小。医生的总体评估显示光老化程度得到明显改善(p<0.05)。所有患者都对治疗效果感到满意或非常满意。副作用轻微且可以逆转,主要为一过性红斑、水肿、脱屑和炎症后色素性沉着。 结论 超脉冲CO2点阵激光治疗面部皮肤光老化高效、安全、副作用轻微且误工时间短。

关键词: 超脉冲;CO2¬点阵激光;点阵式光热分解作用;光老化

Abstract:

Objective To investigate the efficacy, side effects and downtime of a non-sequential fractional ultrapulsed CO2 laser in the treatment of facial photoaged skin. Methods Thirty healthy Chinese women with moderate to severe cutaneous photodamage, rhytids, and dyspigmentation received a single-session, single-pass fractional ultrapulsed CO2 laser resurfacing on the full face. The changes of pigmentation were measured using the Mexameter (Melanin index on the forehead and the highest point of the cheekbone) before the treatment and at the 1, 3-month follow-up visits (M1, M3). The global change of photodamage was evaluated with a 5-point category scale. The patients’ satisfaction was assessed with a 4-point satisfaction scale. Side effects were observed during the treatment and at the M1 and M3 follow-up visits. Results After the treatment, the mean MI both on the forehead and on the cheekbone decreased significantly from the baseline to the follow-up visits (p<0.001) at M1 and M3. All the aspects of cutaneous photodamage obtained significant improvements, including: mottled pigmentation, fine and coarse lines, sallow skin, laxity, enlarged pores, and rough texture. All the patients were satisfied or very satisfied with the results. Adverse reactions, mainly transient erythema, edema, crusting and flaking, and post-inflammatory hyperpigmentation (2/10), were minimal and reversible. Patients could resume their normal life within 7 days. Conclusions Fractional ultrapulsed CO2 laser resurfacing is a good alternative for photoaged facial skin with limited side-effects and short downtime.