中华皮肤科杂志 ›› 2009, Vol. 42 ›› Issue (5): 315-317.

• 论著 • 上一篇    下一篇

梅毒患者外周血单核细胞亚群的研究

韩俊燕1,曾辉1,曾辉1,伦文辉2,闫会文3,刘彦春4,宋映雪5,吴焱6   

  1. 1. 北京地坛医院传染病研究所
    2. 北京地坛医院皮肤性病科
    3. 北京地坛医院STD/AIDS中心
    4. 北京地坛医院性病/艾滋病中心
    5. 北京市地坛医院皮肤科
    6. 北京地坛医院
  • 收稿日期:2008-07-11 修回日期:2008-08-25 出版日期:2009-05-15 发布日期:2009-05-13
  • 通讯作者: 韩俊燕

Peripheral blood monocyte subpopulations in patients with syphilis

  • Received:2008-07-11 Revised:2008-08-25 Online:2009-05-15 Published:2009-05-13

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摘要：

目的 探讨未经治疗的一期、二期和隐性梅毒患者外周血单核细胞亚群的变化。方法 流式细胞仪检测58例未经治疗的梅毒患者（包括隐性梅毒36例，一期梅毒8例，二期梅毒14例）的外周血单核细胞CD14highCD16-亚群和CD14+CD16+亚群。结果 与正常人对照组相比，梅毒患者CD14+CD16+单核细胞所占比例明显升高，所占总单核细胞比例为12.0% ± 5.0%，而CD14highCD16- Mo亚群明显降低，为88.0% ± 5.1%，二者差异均有统计学意义。隐性梅毒、一期梅毒、二期梅毒之间CD14highCD16-亚群和CD14+CD16+亚群差异无统计学意义。结论 未经治疗的梅毒患者外周血单核细胞亚群的变化可能与梅毒螺旋体的持续感染有关，与各临床分期相关性不明显。

关键词: 梅毒;单核细胞

Abstract:

Objective To analyze the changes in peripheral blood monocyte subpopulations in patients with primary, secondary and latent syphilis. Methods Flow cytometry was used to detect CD14highCD16- and CD14+CD16+ monocyte subpopulations in peripheral blood from 58 patients with untreated syphilis, including 36 cases of latent syphilis，8 cases of primary syphilis and 14 cases of secondary syphilis, as well as from 65 normal human controls. Results Compared with the normal controls, the proportion of CD14+CD16+ monocytes among total monocytes was significantly elevated （12.0% ± 5.0% vs 6.0% ± 3.3%, t = 7.25, P < 0.01）, while that of CD14highCD16- monocytes was down-regulated （88.0% ± 5.1% vs 94.0% ± 3.5%, t = -7.20, P < 0.01）. No statistical difference was observed in the proportion of CD14+CD16+ or CD14highCD16- monocytes among the patients with primary syphilis, secondary syphilis and those with latent syphilis （all P > 0.05）. Conclusions The changes in peripheral blood monocyte subpopulation in patients with untreated syphilis may be associated with the permanent infection of Treponema pallidum, but have no obvious correlation with clinical stage of syphilis.