中华皮肤科杂志 ›› 2008, Vol. 41 ›› Issue (9): 621-623.

• 短篇论著 • 上一篇    下一篇

97例慢性光化性皮炎患者作用光谱分析

董碧麟 周飞红 曹永艳 胡志敏 周小勇 闫鸣   

  1. 武汉市第一医院皮肤科 武汉市一医院皮肤科 武汉市第一医院皮肤科门诊 武汉市第一医院皮肤科 武汉市第一医院皮肤科
  • 收稿日期:2007-11-05 修回日期:2007-11-21 发布日期:2008-09-15
  • 通讯作者: 董碧麟 E-mail:augustusdong@126.com

Determination of action spectrum for induction of chronic actinic dermatitis in 97 patients

  

  • Received:2007-11-05 Revised:2007-11-21 Published:2008-09-15

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摘要： 【摘要】 目的 测定慢性光化性皮炎(CAD)的紫外线作用光谱并进一步分析患者病程及日均户外曝光时间对作用光谱最小红斑量(MED)降低的影响。方法 以SUV1000型日光紫外线模拟器为光源，测定108例疑似CAD患者的长波紫外线(UVA)和中波紫外线(UVB)的MED。 结果 108例患者中，97例确诊为CAD。97例患者中，85.57% UVA－MED降低，范围1.02～23.97J/cm2；70.10% UVB－MED降低，范围1.94～19.23mJ/cm2；29.90% 单一UVA－MED下降；14.43% 单一UVB－MED下降。在不同病程组中，>5年组作用光谱的MED显著低于3～5年和<3年组的相应测定值（P<0.01）；3～5年组和<3年组作用光谱的MED之间则无显著性差异（P>0.05）。就日均户外曝光时间而言，>7小时／天组作用光谱的MED显著低于5～7小时／天和<5小时／天组的相应测定值（P<0.01）；而5～7小时／天和<5小时／天组作用光谱的MED之间无显著性差异(P>0.05)。结论 UVA作为CAD的单一作用光谱，不容忽视。且CAD患者病程的发展和户外曝光时间的延长会导致作用光谱MED进一步降低。

关键词: 慢性光化性皮炎, 紫外线, 最小红斑量

Abstract: 【Abstract】 Objective To determine the action spectrum of ultraviolet in chronic actinic dermatitis (CAD) and further analyze the influence of course of disease and period in the sunlight everyday on the decrease of minimal erythema dose (MED) respectively. Methods The MEDs of Ultraviolet A (UVA) and Ultraviolet B (UVB) were measured by SUV 1000 type ultraviolet simulator in 108 presumptive cases of CAD. Results 97 of 108 cases were diagnosed as CAD by a lower UVA-MED and/or UVB-MED. A lower UVA-MED was found in 85.57% of the 97 cases, ranging from 1.02～23.97J/cm2, while a lower UVB-MED in 70.10%, ranging from 1.94～19.23 mJ/cm2. Out of 97 cases, 29.90% was found to be sensitive to UVA alone and 14.43% to UVB alone. As for the course of disease of 97 cases, the MED of action spectrum in above-5-year group was significantly lower than that in 3～5-year group or in <3-year group (P<0.01), while there was no difference of MEDs of action spectrum between 3～5-year group and <3-year group. And for period in the sunlight, the MED of action spectrum in >7-hour/day group was significantly lower than that in 5～7-hour/day and in <5-hour/day group (P<0.01), while no difference of MEDs of action spectrum was found between 5～7-hour/day group and <5-hour/day group (P>0.05). Conclusions UVA alone, as the action spectrum in CAD, should never be ignored. Moreover, the development of course of disease and prolongation of period in the sunlight will further result in the decrease of MED of action spectrum.

Key words: Chronic actinic dermatitis, Ultraviolet, Minimal erythema dose