中华皮肤科杂志 ›› 2007, Vol. 40 ›› Issue (9): 530-532.

• 论著 • 上一篇    下一篇

窄谱中波紫外线治疗早期蕈样肉芽肿的疗效观察

顾俊瑛, 陈明华, 胡跃   

  1. 复旦大学附属华山医院皮肤科, 上海 200040
  • 收稿日期:2006-10-12 出版日期:2007-09-15 发布日期:2007-09-15

Efficacy of narrow-band UVB in the treatment of early stage mycosis fungoides

GU Jun-ying, CHEN Ming-hua, HU Yue   

  1. Department of Dermatology, Huashan Hospital, Fudan University, Shanghai 200040, China
  • Received:2006-10-12 Online:2007-09-15 Published:2007-09-15

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摘要： 目的 探讨窄谱中波紫外线(NB-UVB)治疗早期蕈样肉芽肿(MF)的安全性及有效性.方法 19例患者中,男9例,女10例;年龄20～71岁,平均42.6岁,经组织病理检查证实为MF早期,临床分期ⅠA～ⅠB17例,ⅡA2例.每周NB-UVB照射2～3次,随访1～18个月.结果 13例完全缓解,5例部分缓解,1例无缓解.平均照射次数25.9次,平均累积照射剂量25.6J/cm2.主要不良反应为红斑、瘙痒和色素沉着,患者均能耐受.结论 NB-UVB照射对早期MF疗效确切,不良反应较少.

关键词: 紫外线疗法, 真菌病,蕈样

Abstract: Objective To evaluate the effcacy and safety of narrow-band UVB ( NB-UVB) in the treatment of early stage mycosis fungoides(MF〕.Methods Nineteen patients histopathologically diagnosed as early stage MF, including 9 males and 10 females(aged between 20-71 years with an average of 42.63 year),were enrolled into this prospective open clinical study,Of them, 17 were at stage 1, and 2 at stage Ⅱ A. All patients received topical phototherapy with NB-WB twice or thrice a week, and followed up for 1-18 months. Results Among the 19 patients, 13 achieved complete response(CR),5 achieved partial response(PR),and 1 did not respond. The average radiation frequency was 25.9, and mean accumulated radiation dose 25.6 J/cm2. Main side effects were erythema, pruritus and hyperpigmentation, which were all tolerable. Conclusion NB-UVB is effective for tire treatment of early stave MF with fewer side effects.

Key words: Ultraviolet therapy, Mycosis fungoides