中华皮肤科杂志 ›› 2007, Vol. 40 ›› Issue (2): 80-82.

• 论著 • 上一篇    下一篇

咪喹莫特乳膏治疗鲍恩样丘疹病疗效观察

王宏伟, 王秀丽, 过明霞, 刘放, 乐嘉豫   

  1. 上海市皮肤病性病医院 200050
  • 收稿日期:2006-03-06 发布日期:2007-02-15

Topical imiquimod in the treatment of bowenoid papulosis:a retrospective study

WANG Hong-wei, WANG Xiu-li, GUO Ming-xia, LIU Fang, LE Jia-yu   

  1. Shanghai Skin Diseases and STD Hospital, Shanghai 200050, China
  • Received:2006-03-06 Published:2007-02-15

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摘要： 目的 探讨5%咪喹莫特乳膏治疗鲍恩样丘疹病(BP)的疗效和对复发的影响.方法 回顾性分析39例鲍恩样丘疹病患者,第一组15例,单纯外用5%咪喹莫特乳膏,每周3次,疗程8周.第二组12例,应用CO2激光治疗.第三组12例,CO2激光联合5%咪喹莫特乳膏治疗.三组随访时间均为3个月.结果 第一组33.33%(5/15)的患者获得痊愈,无1例复发,不良反应主要表现为红斑、水肿、糜烂和疼痛,无系统不良反应.第二组CO2激光治疗后,12例全部痊愈,但66.66%(8/12)患者复发.第三组治疗后12例痊愈,仅25%(3/12)患者复发.结论 5%咪喹莫特乳膏是治疗鲍恩样丘疹病的有效药物,尤其是对皮损较小者,疗效好、复发率低.对于肥厚性和/或伴有轻度疣状损害者,CO2激光治疗后联合5%咪喹莫特乳膏可降低复发率.

关键词: 鲍恩样丘疹病, 治疗, 咪喹莫特

Abstract: Objective To evaluate the safety and efficacy of 5% imiquimod cream in the treatment of bowenoid papulosis (BP).Methods A retrospective survey was conducted.Totally,39 patients were divided into 3 groups according to treatment regimen:GroupⅠ(n=15) received 5% imiquimod cream 3 times per week for 8 weeks;GroupⅡ(n=12) received CO2 laser treatment;GroupⅢ(n=12) received CO2 laser treatment followed by 5% imiquimod cream 3 times per week for 8 weeks as adjunctive therapy.All patients were followed up for 3 months.Results In GroupⅠ,the clearance and recurrence rates were 33.33% (5/15) and 0% (0/15),respectively.The most common adverse events were mild to moderate local application site reactions,such as erythema,edema,erosion,and pain.The clearance rates of Group II and Group III were 100%,whereas the recurrence rate at 3 months was significantly lower in GroupⅢthan in GroupⅡ(25% vs 66.66%,P<0.05).Conclusions The results suggest that 5% imiquimod cream is effective for the treatment of bowenoid papulosis,especially for small lesions of bowenoid papulosis with good efficacy and low recurrence,and with CO2 laser treatment it can also reduce the recurrence of plump lesions and/or mild verruca lesions of bowenoid papulosis.

Key words: Bowenoid papulosis, Therapy, Imiquimod