疱疹样皮炎的研究进展

doi:10.35541/cjd.20190931

中华皮肤科杂志 ›› 2021, Vol. 54 ›› Issue (6): 549-553.doi: 10.35541/cjd.20190931

疱疹样皮炎的研究进展

曹珊杨宝琦

山东第一医科大学附属皮肤病医院山东省皮肤病医院山东省皮肤病性病防治研究所，济南 250022

收稿日期:2019-09-24 修回日期:2020-07-10 发布日期:2021-05-31
通讯作者: 杨宝琦 E-mail:baoqiyang@126.com
作者简介:2020年12月之前纸质刊出，中期考核

Dermatitis herpetiformis

Cao Shan, Yang Baoqi

Shandong Provincial Hospital for Skin Diseases & Shandong Provincial Institute of Dermatology and Venereology, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan 250022, China

Received:2019-09-24 Revised:2020-07-10 Published:2021-05-31
Contact: Yang Baoqi E-mail:baoqiyang@126.com

摘要/Abstract

摘要： 【摘要】疱疹样皮炎是一种与乳糜泻相关的自身免疫性大疱病，多发于携带HLA?DQ2或HLA?DQ8等位基因的高加索人。研究表明，疱疹性皮炎患者血清中存在多种针对转谷氨酰胺酶等抗原的抗体，表皮型转谷氨酰胺酶是其自身抗原。疱疹样皮炎的发病除与遗传和麦胶敏感有关外，还可能与肠道菌群微生态失衡有关。无麦胶饮食和氨苯砜仍然是疱疹样皮炎的主要治疗手段。本文从流行病学、发病机制、临床表现、实验室检查、诊断及治疗等方面对疱疹样皮炎进行总结。

关键词: 疱疹样皮炎, 乳糜泻, 诊断, 治疗, 发病机制, 血清学试验

Abstract: 【Abstract】 Dermatitis herpetiformis is an autoimmune bullous disease associated with celiac disease, which occurs mostly in Caucasians carrying HLA-DQ2 or HLA-DQ8 alleles. Studies have shown a variety of antibodies against transglutaminase and other antigens in the serum of patients with dermatitis herpetiformis, and epidermal transglutaminase is an autoantigen. The occurrence of dermatitis herpetiformis is not only associated with genetics and gluten sensitivity, but may also be related to the imbalance of intestinal microbiome. Gluten-free diet and dapsone are still the main therapies for dermatitis herpetiformis. This review summarizes epidemiological features, pathogenesis, clinical manifestations, laboratory findings, diagnosis and treatment of dermatitis herpetiformis.

Key words: Dermatitis herpetiformis, Celiac disease, Diagnosis, Therapy, Pathogenesis, Serologic tests

曹珊杨宝琦. 疱疹样皮炎的研究进展[J]. 中华皮肤科杂志, 2021,54(6):549-553. doi:10.35541/cjd.20190931

Cao Shan, Yang Baoqi. Dermatitis herpetiformis[J]. Chinese Journal of Dermatology, 2021, 54(6): 549-553.doi:10.35541/cjd.20190931

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疱疹样皮炎的研究进展

Dermatitis herpetiformis

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