中华皮肤科杂志 ›› 2003, Vol. 36 ›› Issue (2): 73-75.

• 论著 • 上一篇    下一篇

白癜风患者血清白介素、肿瘤坏死因子α及粒细胞-巨噬细胞集落刺激因子检测

顾劲松, 涂彩霞, 谭雪晶, 谷玲, 林熙然   

  1. 大连医科大学附属第一医院 116011
  • 收稿日期:2002-01-08 出版日期:2003-02-15 发布日期:2003-02-15
  • 基金资助:
    辽宁省科委课题(972290)

Serum Level of Interleukin,Tumor Necrosis Factor Alpha and Granulocyte Macrophage-Colony Stimulating Factor in Patients with Vitiligo

GU Jin-song, TU Cai-xia, TAN Xue-jing, GU Ling, LIN Xi-ran   

  1. Department of Dermatology, The First Affiliated Hospital of Dalian Medical University, Dalian 116011, China
  • Received:2002-01-08 Online:2003-02-15 Published:2003-02-15

摘要: 目的 探讨白介素1β(IL-1β)、白介素6(IL-6)、白介素8(IL-8)、肿瘤坏死因子α(TNF-α)及粒细胞-巨噬细胞集落刺激因子(GM-CSF)等在白癜风患者血清中的变化。方法 采用放射免疫分析法测定50例白癜风患者血清细胞因子水平,并用20例正常人作对照。结果 局限性、泛发性白癜风患者血清IL-6、GM-CSF水平及泛发性患者血清IL-1β水平均显著高于对照组。节段型患者血清细胞因子水平与对照组比较差异无显著性。局限性、泛发性患者血清GM-CSF水平及泛发性患者血清IL-6水平进展期显著高于稳定期。结论 IL-6和GM-CSF在非节段型白癜风自身免疫机制中可能起一定作用。

关键词: 白癜风, 白细胞介素1, 白细胞介素6, 肿瘤坏死因子, 粒细胞巨噬细胞集落刺激因子, 白细胞介素8

Abstract: Objective To study the possible role of cytokines interleukin-1beta(IL-1β),interleukin-6(IL-6),interleukin-8(IL-8),tumor necrosis factor alpha(TNF-α)and granulocyte macrophage colony stimulating factor(GM-CSF)in the pathogenesis of vitiligo.Methods The serum levels of IL-β,IL-6,IL-8,TNF-α,and GM-CSF were measured in 50 patients with vitiligo and 20 healthy volunteers with radioimmunoassay.Results The serum level of IL-6and GM-CSF in focal type and generalized type of vitiligo,and the serum level of IL-1βin generalized type were significantly higher than those in normal controls.In segmental type of vitiligo,the serum levels of all the cytokines tested were not significantly different from those in normal controls.The GM-CSF levels in focal type and generalized type,and the IL-6 level in generalized type of the progressive stage were significantly higher than those in the stable stage.Conclusion IL-6and GM-CSF may be involved in the autoimmune mechanism of non-segmental type of vitiligo.

Key words: Interleukin-6, Interleukin-8, Tumor necrosis factor, Granulocyte-macrophage colony-stimulating factor, Vitiligo, Interleukin-1