中华皮肤科杂志 ›› 2000, Vol. 33 ›› Issue (2): 102-103.

• 论著 • 上一篇    下一篇

别嘌呤醇所致各型药疹的预后与肾功能的关系

陈磊, 潘萌, 郑捷   

  1. 上海第二医科大学附属瑞金医院皮肤科 200025
  • 收稿日期:1999-07-14 发布日期:2000-04-15

The Relationship Between the Prognosis of Allopurinol-Induced Drug Eruption and Renal Function

CHEN Lei, PAN Meng, ZHENG Jie   

  1. Department of Dermatology, Ruijin Hospital, Shanghai Second Medical University, Shanghai 200025
  • Received:1999-07-14 Published:2000-04-15

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摘要： 目的 探讨别嘌呤醇引起的各型药疹的预后与肾功能的关系。方法 对近10年来,病房收治的35例别嘌呤醇药疹进行分析。结果 肾功能损害的程度与病情轻重和皮损类型差异均有显著性(P<0.05),而与疾病的预后组比较,其差异有极显著性(P<0.01)。结论 别嘌呤醇所致的药疹,其肾功能损害的程度与病情的轻重、皮疹类型和疾病的预后密切相关。

关键词: 别嘌呤醇, 药疹, 预后

Abstract: Objective To investigate the relationship between the prognosis of the various types of allopurinol-induced drug eruption and renal function. Methods Thirty-five hospitalized patients with allopurinol-induced drug eruption in our ward during past ten years were reviewed. Results There was a significant difference between the extent of damage to renal function and the severity of drug eruption, as well as the types of rash(P<0.05).The damage to renal function was significantly related to the prognosis of patients(P<0.01). Conclusion It is suggested that the damage to renal function is closely related to the severity of the disease, types of rashes and the prognosis in allopurinol-induced drug eruption.

Key words: Allopurinol, Drug eruptions, Prognosis