中华皮肤科杂志 ›› 1998, Vol. 31 ›› Issue (1): 4-5.

• 论著 • 上一篇    下一篇

系统性红斑狼疮患者T淋巴细胞亚群Fas及bcl-2抗原的表达

蒋莉1, 赵丽娟1, 何春涤2   

  1. 1. 中国医科大学第一临床学院普通内科, 沈阳110001;
    2. 中国医科大学第一临床学院皮肤科
  • 收稿日期:1997-04-20 修回日期:1997-09-26 出版日期:1998-02-15 发布日期:1998-02-15

Expression of Fas and bcl-2 Antigens on T Lymphocyte Subsets in Patients with Systemic Lupus Erythe-matosus

Jiang Li1, Zhao Lijuan1, He Chundi2   

  1. Department of General Internal Medicine, The First Clinical College, China Medical University, Shenyang 110001
  • Received:1997-04-20 Revised:1997-09-26 Online:1998-02-15 Published:1998-02-15

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摘要： 目的 通过对SLE患者末梢血 CD4+、CD8+、CD45RO+ T淋巴细胞亚群表面Fas及bcl-2抗原表达的测定,寻找与SLE发病有关的因素。方法 用流式细胞仪双色解析法。结果 与健康对照组比较,SLE患者的CD4+、CD8+、CD45RO+ T淋巴细胞亚群表面 Fas抗原表达明显增强 (P<0.01),而bcl-2抗原表达明显降低 (P<0.01)。结论 末梢血CD4+、CD8+、CD45RO+ T淋巴细胞亚群表面Fas抗原表达增强,bcl-2抗原表达降低即过度细胞凋亡现象可能与SLE发病有关。

关键词: 红斑狼疮,系统性, T淋巴细胞亚群, Fas, bcl-2

Abstract: Objective To study the expression of Fas and bcl-2 antigens on T lymphocyte subsets in patients with SLE and healthy controls.Methods Flow cytometry(two colour analysis) were used. Results We observed thatthe expression of Fas antigen on CD4+,CD8+,CD45RO+ T lymphocyte subsets of SLE patients was significantly higher than that of healthy controls(P<0.01) and thatthe expression of bcl-2 antigen was significantly decreased(P<0.01).Conclusion Increased expression of Fas antigen and decreased expression of bcl-2 antigen on T lymphocyte subsets may be related to the pathogenesis of SLE.

Key words: Lupus erythematosus,systemic, T lymphocyte subset, Fas, bcl-2