中华皮肤科杂志 ›› 1998, Vol. 31 ›› Issue (1): 20-21.

• 论著 • 上一篇    下一篇

多发性肌炎/皮肌炎患者血清肿瘤坏死因子α水平及临床关系的观察

谷丽红1, 梁再赋1, 张士发2, 白兆震1, 陈洪铎1   

  1. 1. 中国医科大学第一临床学院皮肤科, 沈阳110001;
    2. 沈阳军区总医院皮肤科
  • 收稿日期:1997-01-18 修回日期:1997-05-20 出版日期:1998-02-15 发布日期:1998-02-15

Study on the Serum Level of Tumor Necrosis Factor-α and Its Relationship with Some Clinical Parameters in Polymyositis/Dermatomyositis

Gu Lihong1, Liang Zaifu1, Zhang Shifa2   

  1. Department of Dermatology, No.1 Hospital of China Medical University, Shenyang 110001
  • Received:1997-01-18 Revised:1997-05-20 Online:1998-02-15 Published:1998-02-15

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摘要： 目的 探讨肿瘤坏死因子 (TNF)与多发性肌炎/皮肌炎 (PM/DM)发病机理的关系。方法 用双抗体夹心ELISA法检测了24例PM/DM患者和18例正常人TNFα水平,并分析了其与临床相关实验室指标的关系。结果 18例正常人血清中未测出TNFα,而24例患者中9例TNFα水平升高。可测出TNFα的PM/DM患者组与未测出患者组比较前者具有:1高尿肌酸水平 (P<0.01);2低尿肌酐水平 (P<0.05);3血沉高 (P<0.01);血清肌酶两者之间未见明显差异。结论 TNFα水平与PM/DM的活动性相关,TNFα可能在PM/DM的发病机理中起着重要作用。

关键词: 多发性肌炎, 皮肌炎, 肿瘤坏死因子

Abstract: Objective To study the relationship between tumor necrosis factor(TNF) and the pathogenesis of polymyositis/dermatomyositis(PM/DM).Methods The serum levels of TNF-α were determined in 24 patients with PM/DM and 18 normal controls by double antibody sandwich ELISA method, and then their relationship with some clinically related laboratory parameters was analyzed.Results The results showed that the TNF-α was not detected in the control group,and the level of TNF-α was increased in 9 of 24 patients with PM/DM.In com parison with the group with elevated TNF-α to the group without,we found the group with elevated TNF-α had:(1) a higher level of urinary creatine(P<0.01). (2) a lower level of urinary creatinine(P<0.05). (3) increased level of ESR (P<0.01). (4) no difference in serum levels of CPK,LDH and AST.Conclusion Our results indicate that there is a relationship between TNF-α level and the disease activity of PM/DM,and TNF-α may play an important role in the pathogenesis of PM/DM.

Key words: Polymyositis, Dermatomyositis, Tumornecrosis factor