中华皮肤科杂志 ›› 1998, Vol. 31 ›› Issue (1): 14-15.

• 论著 • 上一篇    下一篇

系统性红斑狼疮患者外周血淋巴细胞CD43抗原的研究

梁再赋1, 张士发2, 许静1, 冯永山1, 王壮志1, 顾绍裘1   

  1. 1. 中国医科大学第一临床学院皮肤科, 沈阳110001;
    2. 沈阳军区总医院皮肤科
  • 收稿日期:1997-07-15 修回日期:1997-10-05 出版日期:1998-02-15 发布日期:1998-02-15

Preliminary Study of Expression of CD43 Antigen on Lymphocytes of Peripheral Blood in Patients with SLE

Liang Zaifu1, Zang Shifa2, Xu Jing1   

  1. Department of Dermatology, No.1 Hospital of China Medical University, Shenyang 110001
  • Received:1997-07-15 Revised:1997-10-05 Online:1998-02-15 Published:1998-02-15

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摘要： 目的 探讨SLE免疫功能异常的原因。方法 采用免疫荧光双标记-流式细胞仪检测了16例活动期SLE患者外周血淋巴细胞的CD43抗原。结果 1活动期 SLE患者外周血CD43抗原阳性淋巴细胞为63.14±16.47,低于正常人对照组86.62±12.86,有非常显著性差异 (P<0.01);2 CD43抗原阳性淋巴细胞数与SLE疾病活动度呈显著负相关,r=-0.70 2,P<0.01;3活动期 SLE患者外周血CD19+-CD43+淋巴细胞为2.55±1.38,高于对照组1.32±0.92,有非常显著性差异 (P<0.01)。结论 CD19+-CD43+淋巴细胞的增多可能与SLE大量产生抗DNA自身抗体有关。

关键词: 红斑狼疮,系统性, 流式细胞计数, CD43

Abstract: Objective To investigate the causes of immunological disorders in SLE.Methods CD43 antigen on lymphocytes of peripheral blood in 16 cases of active SLE was detected by immunoflourescent double marker-flow cytometry.Results The results showed that,(1) the number of CD43 antigen positive lymphocytes in peripheral blood of active SLE patients was 63.14±16.47,which was significantly lower than that of the control group(86.6 2±12.86,P<0.01).(2) The number of CD43 antigen positive cells was negatively correlated to the disease activity of SLE (r=-0.702,P<0.01). (3) The number of CD19+-CD43+ lymphocytes in peripheral blood in active SLE was 2.5 5±1.38w hich was significantly higher than that of the control group (1.32±0.92,P<0.01).Conclusion The increase of CD19+-CD43+ lymphocytes may be correlated with the production of anti-DNA autoantibody in SLE.

Key words: Lupus erythematosus, systemic Flowcytometry, CD43