中华皮肤科杂志 ›› 1998, Vol. 31 ›› Issue (1): 16-17.

• 论著 • 上一篇    下一篇

用肾图定量分析法评价系统性红斑狼疮患者的肾脏损害

罗迪青1, 钟幸福1, 许德清1, 蒋宁一2   

  1. 1. 中山医科大学孙逸仙纪念医院皮肤科, 广州510120;
    2. 中山医科大学孙逸仙纪念医院核医学科, 广州510120
  • 收稿日期:1996-11-18 修回日期:1997-05-14 出版日期:1998-02-15 发布日期:1998-02-15

Clinical Significance of Renal Imaging in Pateints with SLE by Quantitative Renogram

Luo Diqing1, Zhong Xingfu1, Xu Deqing1   

  1. Department of Dermatology, Sun Yat-sen University of Medical Sciences, Guangzhou 510120
  • Received:1996-11-18 Revised:1997-05-14 Online:1998-02-15 Published:1998-02-15

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摘要： 目的 探讨系统性红斑狼疮患者肾功能损害的敏感指标。方法 用99m Tc-DTPA作示踪剂,对58例患者进行常规肾显像,测定肾小球滤过率,并对肾图进行定量分析。结果 用Gates法计算的肾小球滤过率与肌酐清除率有高度相关性。肾小球滤过率的改变与患病时间长短无关。本组中肾图异常者为50%,但肾图经定量分析后,半排时间、15分钟残余率的异常率分别为93.1%和85.3%,远较临床综合判断有67.3%的患者肾功能受损为高。即使是肾小球滤过率在正常范围时,亦有88.5%的患者显示半排时间延长。此外,半排时间与15分钟残余率对肾异常的检出率比尿素氮和(或)肌酐明显为高。结论 对肾图进行定量分析可提高其对肾脏功能损害判断的敏感性。

关键词: 红斑狼疮,系统性, 肾显像

Abstract: Objective To investigate the sensitive indexes which can diagnose early renal damage in SLE.Methods We used radioisotope renogram with 99m Tc-DTPA as a tracer,to examine the glomerular filtration rate(GFR) and assessed renogram quantitatively in 58 patients.Results The results showed that the GFR calculated by the Gates method correlated well with creatinine clearance rate,but had no correlation with the duration of the disease.Only 50% of the patients showed abnormal renogram.There were abnormal half clearance time and 15-minute residual ratio in 93.1% and 85.3% of the patients respectively after quantitative renogramanalysis.However,there were only 67.3% of patients had renal damage clinically,the positive rates of half clearance time and 15-minute residual ratio were much higher than those found by clinical examination.Even when GFR was normal,there were 88.5% of the patients showed prolonged half clearance time.We also found that half clearance time and 15-minute residual ratio were much more sensitive than blood urea nitrogen or/and creatinine clearance rate determination.Conclusion The results suggest that quantitative renogramanalysis may increase the sensitivity in assessing the renal damage.

Key words: Lupus erythematosus, systemic, Renogram