中华皮肤科杂志 ›› 1997, Vol. 30 ›› Issue (1): 16-18.

• 论著 • 上一篇    下一篇

类天疱疮不同分子量靶抗原抗体与临床关系的探讨

杜卫1, 翁孟武2, 徐明2   

  1. 1. 上海医科大学附属中山医院, 200032;
    2. 上海医科大学附属华山医院, 200032
  • 收稿日期:1995-12-22 修回日期:1996-09-10 出版日期:1997-02-15 发布日期:1997-02-15

Study of Relationship between the Target Antigens of Different Molecular Weights and the Clinical Characteristics in Bullous Pemphigoid

Du Wei1, Weng Mengwu2, Xu Ming2   

  1. Zhongshan Hospital, Shanghai Medical University, Shanghai 200032
  • Received:1995-12-22 Revised:1996-09-10 Online:1997-02-15 Published:1997-02-15

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摘要： 为了探讨类天疱疮的两种不同分子量靶抗原与其临床的关系,用免疫印迹法检测62例类天疱疮患者血清.结果表明,结合230000靶抗原的有30例(48.4%),结合165000靶抗原的有41例(66.1%),且发病时血清测到抗230000和165000抗原的自身抗体的4例患者,在稳定期仅可测到165000的抗体.分析了识别不同分子量靶抗原的类天疱疮病例与其临床表现、疗效及预后的关系,结果提示:结合165000靶抗原的病例临床症状较轻,控制病情所需皮质类固醇激素量较小,复发时水疱较小.

关键词: 类天疱疮,疱性, 抗原, 皮肤表现

Abstract: In order to study the relationship between two kinds of bullous pemphigoid (BP) antigens, we measured the sera from 62 cases of BP using immunoblotting (IB). The results indicated:230 000 target antigen (BPAG1) could be identified in 30 cases of BP (48.4%), but 165 000 target antigen (BPAG2), in 41 cases of BP (66.1%). Meanwhile, the sera of 4 cases, which identified both BPAG1 and BPAG2 during active period, only bound with BPAG2 during stable period. After analyzing the clinical manifestation, effects of treatment and prognosis in BP whose sera identified different BAG. We found out that the cases whose sera only bound BPAG2 had mild clinical symptoms, the dosage of corticosteroid was lower and the recurrent blisters were smaller.

Key words: Pemphigoid,bullous, Antigens, Skin manifestations