中华皮肤科杂志 ›› 1996, Vol. 29 ›› Issue (1): 41-42.

• 论著 • 上一篇    下一篇

皮肤鳞状上皮细胞肿瘤中p53蛋白的表达

李东霞1, 涂平2, 马圣清2   

  1. 1. 内蒙古医学院附属医院皮肤科, 呼和浩特010050;
    2. 北京医科大学第一医院皮肤科
  • 收稿日期:1995-04-12 修回日期:1995-06-26 出版日期:1996-02-15 发布日期:1996-02-15

Study of P53 in Cutaneous Squamous Epithelial Cell Tumour

Li Dongxia1, Tu Ping2, Ma Shengqing2   

  1. Department of Dermatology, The Affiliated Hospital of Inner Mongolia Medical College, Huhhot 010050
  • Received:1995-04-12 Revised:1995-06-26 Online:1996-02-15 Published:1996-02-15

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摘要： 基因突变在肿瘤的发病机制中起着重要作用。p53基因有2种类型,野生型和突变型。为了探讨p53基因突变与皮肤鳞状上皮细胞肿瘤发生、发展的关系,本研究采用一种新的免疫组化技术标记的链霉亲和素-生物素连接系统对29例皮肤鳞状上皮细胞肿瘤皮损进行免疫组化研究。结果3/6例日光性角化p53染色阳性,p53阳性细胞局限于表皮基底部位非典型细胞增生区域。6/10例Bowen病和8/13例鳞状细胞癌p53染色阳性,p53阳性细胞弥漫分布于肿瘤组织全层。提示p53基因突变在皮肤鳞状上皮细胞肿瘤的发生、发展中起着重要作用。

关键词: p53, 突变, 皮肤, 肿瘤

Abstract: Gene mutation is known to play an important role in carcinogenesis.There are two types of p53 gene,wild-type and mutant-type.In order to observe the relationship between p53 gene mutation and cutaneous squarnous epithelial ceil tumours,immunohistochemical study was carried out for p53 ex-pression in the epidermis from 29 patients with cutaneous squamous epithelial cell tumouts using a new immunohistochemical technique labelled streptavidin biotin system.The results showed that p53 positive staining was only confined to areas of atypical proliferation of epithelia in 3/6 cases of actinic keratosis. 6/10 cases of Bowen's disease and 8/13 cases of squamous cell carcinoma showed that p53 positive staining was seen throughout the tumour.It is suggested that p53 gene mutation might play an impor-tant role in cutaneous squamous epithlial cell tumour formation.

Key words: p53, Mutation, Cutaneous, Tumour