中华皮肤科杂志 ›› 2019, Vol. 52 ›› Issue (2): 100-102.doi: 10.3760/cma.j.issn.0412-4030.2019.02.006

• 研究报道 • 上一篇    下一篇

残疾基因同源物2相互作用蛋白在皮肤基底细胞癌中的表达及临床意义

袁绍萍1    温炬2    李常兴3    田歆4    秦思2    张青华2   

  1. 1南方医科大学第二临床医学院，广州 510630；2广东省第二人民医院皮肤科，广州 510317；3南方医科大学南方医院皮肤科，广州 523008；4广州市皮肤性病防治所，510095
  • 收稿日期:2018-03-14 修回日期:2018-08-25 出版日期:2019-02-15 发布日期:2019-01-29
  • 通讯作者: 温炬 E-mail:gdwenju@163.com
  • 基金资助:
    广东省自然科学基金（2015A030313685）

Disabled homolog 2 interacting protein expression in basal cell carcinoma of the skin and its clinical significance

Yuan Shaoping1, Wen Ju2, Li Changxing3, Tian Xin4, Qin Si 2, Zhang Qinghua2   

  1. 1Second Clinical Medicine School, Southern Medical University, Guangzhou 510630, China; 2Department of Dermatology, Guangdong Second Provincial General Hospital, Guangzhou 510317, China; 3Department of Dermatology, Nanfang Hospital, Southern Medical University, Guangzhou 523008, China; 4Guangzhou Institute of Dermatology, Guangzhou 510095, China
  • Received:2018-03-14 Revised:2018-08-25 Online:2019-02-15 Published:2019-01-29
  • Contact: Wen Ju E-mail:gdwenju@163.com
  • Supported by:
    Natural Science Foundation of Guangdong Province of China （2015A030313685）

PDF

5

赞

摘要： 【摘要】 目的 探讨残疾基因同源物2相互作用蛋白（DAB2IP）基因在皮肤基底细胞癌组织中的表达及临床意义。方法 采用回顾性分析方法，选择2012年1月至2017年11月在广东省第二人民医院皮肤科以及广州市皮肤病防治所门诊或住院接受皮肤肿物切除且资料完整的患者105例，其中病理证实为皮肤基底细胞癌患者79例作为病例组，除皮损外无其他明显临床症状、且病理证实为良性皮赘患者26例作为对照组。免疫组化法检测两组中DAB2IP的表达，分析DAB2IP表达水平与皮肤基底细胞癌临床表型及病理的相关性。采用SPSS21.0统计软件进行统计分析，计数资料比较采用χ2检验。结果 DAB2IP蛋白在对照组26例中阳性11例（42.3%），病例组79例中阳性74例（93.7%），两组比较，差异有统计学意义（χ2 = 33.50，P < 0.05）。DAB2IP表达与皮肤基底细胞癌患者性别、年龄、肿瘤大小无关（均P > 0.05），浅表性组（5/7）浸润性组（95.8%）DAB2IP阳性表达率差异有统计学意义（χ2 = 6.47，P < 0.05）。79例皮肤基底细胞癌中，Ki?67蛋白阳性31例（39.2%），且表达Ki?67的癌细胞都表达DAB2IP。结论 DAB2IP在皮肤基底细胞癌中表达增加，可能与皮肤基底细胞癌的发生和浸润有关。

关键词: 肿瘤, 基底细胞； Ki?67抗原； 残疾基因同源物2相互作用蛋白

Abstract: 【Abstract】 Objective To determine the expression of disabled homolog 2 interacting protein （DAB2IP） gene in the basal cell carcinoma （BCC） of the skin, and to investigate its clinical significance. Methods Clinical data were retrospectively analyzed in 105 outpatients and inpatients who received skin mass resection in Department of Dermatology, Guangdong Second Provincial General Hospital and Guangzhou Institute of Dermatology between January 2012 and November 2017. Totally, 79 patients with pathologically diagnosed BCC of the skin served as patient group, and 26 patients with pathologically diagnosed skin tag but without other clinical manifestations served as control group. Immunohistochemical staining was performed to determine the expression of DAB2IP in the two groups, and correlations of the DAB2IP expression with the clinical phenotype and pathological features of BCC of the skin were analyzed. Statistical analysis was carried out with SPSS21.0 software by using chi-square test for the comparison of enumeration data. Results The protein expression of DAB2IP was observed in 11 （42.3%） of 26 patients in the control group, as well as in 74 （93.7%） of 79 patients in the patient group, and there was a significant difference in the positive rate of DAB2IP protein between the two groups （χ2 = 33.50, P < 0.05）. The expression of DAB2IP was uncorrelated with gender or age of patients with BCC of the skin, or with the tumor size （all P > 0.05）. The positive rate of DAB2IP protein significantly differed between the patients with superficial BCC （5/7） and those with invasive BCC （95.8%, 69/72; χ2 = 6.47, P < 0.05）. Of the 79 patients with BCC of the skin, Ki-67 protein was detected in 31 （39.2%）, and the cancer cells expressing Ki-67 protein also expressed DAB2IP protein. Conclusion The expression of DAB2IP increases in BCC of the skin, which may be associated with the occurrence and infiltration of BCC of the skin.

Key words: Neoplasms, basal cell, Ki?67 antigen, Disabled homolog 2 interacting protein