托法替布治疗成人深在型环状肉芽肿1例

doi:10.35541/cjd.20230653

中华皮肤科杂志 ›› 2025, e20230653.doi: 10.35541/cjd.20230653

托法替布治疗成人深在型环状肉芽肿1例

孟慧娟林清霞张东马伟元

潍坊医学院附属医院皮肤科，潍坊 261041

收稿日期:2023-11-10 修回日期:2024-06-29 发布日期:2025-02-10
通讯作者: 马伟元 E-mail:fymaweiyuan@wfmc.edu.cn
基金资助:
潍坊医学院附属医院科研创新计划项目（2022BSQD07）

Successful treatment of a case of deep granuloma annulare with tofacitinib

Meng Huijuan, Lin Qingxia, Zhang Dong, Ma Weiyuan

Department of Dermatology, Affiliated Hospital of Weifang Medical University, Weifang 261041, Shandong, China

Received:2023-11-10 Revised:2024-06-29 Published:2025-02-10
Contact: Ma Weiyuan E-mail:fymaweiyuan@wfmc.edu.cn
Supported by:
Affiliated Hospital of Weifang Medical University Scientific Research Project（2022BSQD07）

摘要/Abstract

摘要： 患者男，51岁，因腹部皮下结节半年就诊。患者半年前无明显诱因腹部出现一黄豆粒大小的皮下结节，无明显自觉症状，逐渐增大……

中图分类号:

孟慧娟林清霞张东李美玲. 托法替布治疗成人深在型环状肉芽肿1例[J]. 中华皮肤科杂志, 2025,e20230653. doi:10.35541/cjd.20230653

Meng Huijuan, Lin Qingxia, Zhang Dong, Ma Weiyuan. Successful treatment of a case of deep granuloma annulare with tofacitinib[J]. Chinese Journal of Dermatology,2025,e20230653. doi:10.35541/cjd.20230653

参考文献 7

［1］	Wang YF, Geng Y, Xu XL. Generalized interstitial granuloma annulare with tuberculosis and cutis laxa: a rare case report. Int J Dermatol Venereol, 2023,6（3）:172⁃174. doi: 10.1097/JD9.000 0000000000060.
［2］	Lukács J, Schliemann S, Elsner P. Treatment of generalized granuloma annulare ⁃ a systematic review［J］. J Eur Acad Dermatol Venereol, 2015,29（8）:1467⁃1480. doi: 10.1111/jdv.12976.
［3］	Barbieri JS, Rosenbach M, Rodriguez O, et al. Association of granuloma annulare with type 2 diabetes, hyperlipidemia, autoimmune disorders, and hematologic malignant neoplasms［J］. JAMA Dermatol, 2021,157（7）:817⁃823. doi: 10.1001/jamadermatol.2021.1805.
［4］	Min MS, Wu J, He H, et al. Granuloma annulare skin profile shows activation of T⁃helper cell type 1, T⁃helper cell type 2, and Janus kinase pathways［J］. J Am Acad Dermatol, 2020,83（1）:63⁃70. doi: 10.1016/j.jaad.2019.12.028.
［5］	Damsky W, Thakral D, McGeary MK, et al. Janus kinase inhibition induces disease remission in cutaneous sarcoidosis and granuloma annulare［J］. J Am Acad Dermatol, 2020,82（3）:612⁃621. doi: 10.1016/j.jaad.2019.05.098.
［6］	Wang A, Rahman NT, McGeary MK, et al. Treatment of granuloma annulare and suppression of proinflammatory cytokine activity with tofacitinib［J］. J Allergy Clin Immunol, 2021,147（5）:1795⁃1809. doi: 10.1016/j.jaci.2020.10.012.
［7］	Damsky W, King BA. Treatment of granuloma annulare with tofacitinib 2% ointment［J］. JAAD Case Rep, 2020,6（1）:69⁃71. doi: 10.1016/j.jdcr.2019.10.016.

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托法替布治疗成人深在型环状肉芽肿1例

Successful treatment of a case of deep granuloma annulare with tofacitinib

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