中华皮肤科杂志 ›› 2023, Vol. 56 ›› Issue (8): 799-802.doi: 10.35541/cjd.20201257

• 综述 • 上一篇    

二甲双胍治疗银屑病的研究进展

陈小敏    张景展    丁媛    康晓静   

  1. 新疆维吾尔自治区人民医院皮肤性病科,乌鲁木齐  830001
  • 收稿日期:2020-12-31 修回日期:2021-12-12 发布日期:2023-08-07
  • 通讯作者: 丁媛;康晓静 E-mail:dydyuan@126.com; kangxiaojing163@163.com
  • 基金资助:
    新疆维吾尔自治区人民医院院级课题(20190106)

Metformin in the treatment of psoriasis

Chen Xiaomin, Zhang Jingzhan, Ding Yuan, Kang Xiaojing   

  1. Department of Dermatology and Venereology, People′s Hospital of Xinjiang Uygur Autonomous Region, Urumqi 830001, China
  • Received:2020-12-31 Revised:2021-12-12 Published:2023-08-07
  • Contact: Ding Yuan; Kang Xiaojing E-mail:dydyuan@126.com; kangxiaojing163@163.com
  • Supported by:
    Hospital-Level Project of People′s Hospital of Xinjiang Uygur Autonomous Region(20190106)

摘要: 【摘要】 二甲双胍是2型糖尿病的一线治疗药物,目前也逐渐用于皮肤病的治疗,包括银屑病等。本文综述二甲双胍治疗银屑病的机制及临床研究进展,为皮肤科治疗银屑病尤其是银屑病合并代谢性疾病提供思路和方法。

关键词: 银屑病, 二甲双胍, 治疗, NF-κB, mTOR, ERK1/2, STAT, NLRP3

Abstract: 【Abstract】 Metformin, the first-line treatment of type 2 diabetes, has been also increasingly used in the treatment of some skin diseases, such as psoriasis. This review summarizes therapeutic mechanisms of and clinical research progress in metformin in the treatment of psoriasis, aiming to provide ideas and methods for the treatment of psoriasis, especially psoriasis complicated by metabolic diseases.

Key words: Psoriasis, Metformin, Therapy, NF-kappa B, Mechanistic target of rapamycin, Extracellular signal-regulated kinase, Signal transducing activator of transcription, Nucleotide-binding oligomerization domain-like receptor protein 3

引用本文

陈小敏 张景展 丁媛 康晓静. 二甲双胍治疗银屑病的研究进展[J]. 中华皮肤科杂志, 2023,56(8):799-802. doi:10.35541/cjd.20201257

Chen Xiaomin, Zhang Jingzhan, Ding Yuan, Kang Xiaojing. Metformin in the treatment of psoriasis[J]. Chinese Journal of Dermatology, 2023, 56(8): 799-802.doi:10.35541/cjd.20201257