中华皮肤科杂志 ›› 2021, Vol. 54 ›› Issue (2): 161-164.doi: 10.35541/cjd.20201028

• 专家视角 • 上一篇    下一篇

特应性皮炎的治疗进展:新药物、新手段、新模式

宋志强 王欢   

  1. 陆军军医大学西南医院皮肤科,重庆  400038
  • 收稿日期:2020-10-21 修回日期:2020-12-01 发布日期:2021-01-29
  • 通讯作者: 宋志强 E-mail:zhiqiang.song@hotmail.com

Advances in the treatment of atopic dermatitis: new medications, new methods and new models

Song Zhiqiang, Wang Huan   

  1. Department of Dermatology, The Southwest Hospital of Army Medical University, Chongqing 400038, China
  • Received:2020-10-21 Revised:2020-12-01 Published:2021-01-29
  • Contact: Song Zhiqiang E-mail:zhiqiang.song@hotmail.com

摘要: 【摘要】 特应性皮炎是一种反复发作的炎症性皮肤病,现有的治疗方法虽能缓解症状,但仍存在一定的局限性及不良反应。近年来,随着特应性皮炎关键炎症分子的发现和靶向治疗药物的开发,给临床带来一些新的治疗方法和理念。了解特应性皮炎相关生物制剂、小分子药物、辅助治疗、监测手段和疾病管理模式新进展,有助于临床医生更好地治疗及管理特应性皮炎患者。

关键词: 皮炎, 特应性, 治疗, 受体, 白细胞介素4, Janus激酶类, 抗体, 单克隆, 度普利尤单抗

Abstract: 【Abstract】 Atopic dermatitis is a recurrent inflammatory skin disease. Although the existing systemic and topical treatment can relieve symptoms, there are still some limitations and adverse effects. In recent years, with the in-depth study on the pathogenesis of atopic dermatitis, especially the discovery of key inflammatory molecules and development of targeted therapeutic drugs, some new therapeutic methods and concepts have been brought to clinical practice. Awareness of new progress in atopic dermatitis-related ?biologics, small-molecule drugs, adjuvant treatment, monitoring methods and models for managing disease, will help clinicians better treat and manage atopic dermatitis.

Key words: Dermatitis, atopic, Therapy, Receptors, interleukin-4, Janus kinases, Antibodies, monoclonal, Dupilumab